2. Academic Validation
  3. Quinoline and quinolone dimers and their biological activities: An overview

Quinoline and quinolone dimers and their biological activities: An overview

  • Eur J Med Chem. 2019 Jan 1:161:101-117. doi: 10.1016/j.ejmech.2018.10.035.
Xue-Mei Chu 1,  Cong Wang 2,  Wen Liu 1,  Li-Li Liang 1,  Kai-Kai Gong 3,  Cheng-Ying Zhao 4,  Kun-Lai Sun 5
Affiliations

Affiliations

  • 1 Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, 316022, PR China.
  • 2 Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, School of Chemistry and Chemical Engineering, Guangxi University of Nationalities, Nanning, 530006, PR China.
  • 3 Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, 256603, PR China.
  • 4 Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China.
  • 5 Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, 316022, PR China. Electronic address: sunqinlai@126.com.
PMID: 30343191 DOI: 10.1016/j.ejmech.2018.10.035
Abstract

Quinoline and Quinolone motifs which act as structural subunits of more complex natural products are ubiquitous in nature, and they are useful pharmacophores which play a pivotal role in drug development. Compared with the corresponding monomeric compounds, the dimers usually exhibited some unique properties, so dimers have caused great interests in recent years. Quinline and Quinolone dimers possess various biological properties such as Antibacterial, Anticancer, antimalarial and antitubercular activities, and some of them which are exemplified by piperaquine have already used in clinical practice. Numerous quinline and Quinolone dimers have been synthesized and screened for their in vitro and in vivo biological activities, and some of them exhibited promising potency. Therefore, quinline and Quinolone dimers have the potential for clinical deployment in the control and eradication of various diseases. This review covers the recent advances of quinline and Quinolone dimers as bioactive substances. The structure-activity relationship was also discussed to provide an insight for rational designs of more active quinline and Quinolone dimers.

Keywords

Antibacterial; Anticancer; Antimalarial; Antitubercular; Dimer; Quinoline; Quinolone; Structure-activity relationship.

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