2. Academic Validation
  3. Implantable system for chronotherapy

Implantable system for chronotherapy

  • Sci Adv. 2021 Nov 26;7(48):eabj4624. doi: 10.1126/sciadv.abj4624.
Seung Ho Lee 1,  Qianqian Wan 1,  Adam Wentworth 1 2,  Ian Ballinger 2,  Keiko Ishida 1 2,  Joy E Collins 1 2,  Siddartha Tamang 1,  Hen-Wei Huang 1 2,  Canchen Li 1,  Kaitlyn Hess 1,  Aaron Lopes 1 2,  Ameya R Kirtane 1 2,  Jung Seung Lee 1 3,  SeJun Lee 1,  Wei Chen 1,  Kaitlyn Wong 2,  George Selsing 1 2,  Hyunjoon Kim 1,  Stephen T Buckley 4,  Alison Hayward 1 2 5,  Robert Langer 1 6 6,  Giovanni Traverso 1 2 6
Affiliations

Affiliations

  • 1 The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • 2 Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
  • 3 Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.
  • 4 Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • 5 Global Research Technologies, Novo Nordisk A/S, Måløv, Denmark.
  • 6 Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
PMID: 34826238 DOI: 10.1126/sciadv.abj4624
Abstract

Diurnal variation in enzymes, Hormones, and other biological mediators has long been recognized in mammalian physiology. Developments in pharmacobiology over the past few decades have shown that timing drug delivery can enhance drug efficacy. Here, we report the development of a battery-free, refillable, subcutaneous, and trocar-compatible implantable system that facilitates chronotherapy by enabling tight control over the timing of drug administration in response to external mechanical actuation. The external wearable system is coupled to a mobile app to facilitate control over dosing time. Using this system, we show the efficacy of bromocriptine on glycemic control in a diabetic rat model. We also demonstrate that antihypertensives can be delivered through this device, which could have clinical applications given the recognized diurnal variation of hypertension-related complications. We anticipate that implants capable of chronotherapy will have a substantial impact on our capacity to enhance treatment effectiveness for a broad range of chronic conditions.

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