2. Academic Validation
  3. Triazole-fused pyrimidines in target-based anticancer drug discovery

Triazole-fused pyrimidines in target-based anticancer drug discovery

  • Eur J Med Chem. 2023 Mar 5:249:115101. doi: 10.1016/j.ejmech.2023.115101.
Xing-Jie Dai 1,  Lei-Peng Xue 1,  Shi-Kun Ji 1,  Ying Zhou 1,  Ya Gao 1,  Yi-Chao Zheng 1,  Hui-Min Liu 2,  Hong-Min Liu 1
Affiliations

Affiliations

  • 1 Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan Province, China.
  • 2 Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan Province, China. Electronic address: liuhuimin@zzu.edu.cn.
PMID: 36724635 DOI: 10.1016/j.ejmech.2023.115101
Abstract

In recent decades, the development of targeted drugs has featured prominently in the treatment of Cancer, which is among the major causes of mortality globally. Triazole-fused pyrimidines, a widely-used class of heterocycles in medicinal chemistry, have attracted considerable interest as potential Anticancer agents that target various cancer-associated targets in recent years, demonstrating them as valuable templates for discovering novel Anticancer candidates. The current review concentrates on the latest advancements of triazole-pyrimidines as target-based Anticancer agents, including works published between 2007 and the present (2007-2022). The structure-activity relationships (SARs) and multiple pathways are also reviewed to shed light on the development of more effective and biotargeted Anticancer candidates.

Keywords

Anticancer target; Drug discovery; SARs; Small molecule inhibitors; Triazole-fused pyrimidines.

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