2. Academic Validation
  3. Targeting autophagy with small-molecule activators for potential therapeutic purposes

Targeting autophagy with small-molecule activators for potential therapeutic purposes

  • Eur J Med Chem. 2023 Nov 15:260:115722. doi: 10.1016/j.ejmech.2023.115722.
Zhichao Fan 1,  Lin-Xi Wan 2,  Wei Jiang 1,  Bo Liu 3,  Dongbo Wu 4
Affiliations

Affiliations

  • 1 Center of Infectious Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
  • 2 Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
  • 3 Center of Infectious Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: liubo2400@163.com.
  • 4 Center of Infectious Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: dongbohuaxi@scu.edu.cn.
PMID: 37595546 DOI: 10.1016/j.ejmech.2023.115722
Abstract

Autophagy is well-known to be a lysosome-mediated catabolic process for maintaining cellular and organismal homeostasis, which has been established with many links to a variety of human diseases. Compared with the therapeutic strategy for inhibiting Autophagy, activating Autophagy seems to be another promising therapeutic strategy in several contexts. Hitherto, mounting efforts have been made to discover potent and selective small-molecule activators of Autophagy to potentially treat human diseases. Thus, in this perspective, we focus on summarizing the complicated relationships between defective Autophagy and human diseases, and further discuss the updated progress of a series of small-molecule activators targeting Autophagy in human diseases. Taken together, these inspiring findings would provide a clue on discovering more small-molecule activators of Autophagy as targeted candidate drugs for potential therapeutic purposes.

Keywords

Autophagic target; Autophagy; Candidate drug; Human disease; Small-molecule activator.

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