2. Academic Validation
  3. Dual-function MgSrCeAl-LDH nanosheets enable both ROS clearance and enhanced angiogenesis for myocardial ischemia/reperfusion injury therapy

Dual-function MgSrCeAl-LDH nanosheets enable both ROS clearance and enhanced angiogenesis for myocardial ischemia/reperfusion injury therapy

  • J Nanobiotechnology. 2025 Oct 27;23(1):690. doi: 10.1186/s12951-025-03673-8.
Jiayi Shen # 1,  Yuwen Luo # 2,  Wuming Hu # 1,  Susu Zhang # 1,  Yu Yang 3,  Linwen Lan 1,  Enqian Liu 1,  Jian Xu 1,  Tingting Hu 4 5,  Jingjun Nie 2,  Dafu Chen 6,  Ruizheng Liang 7 8,  Lingchun Lyu 9
Affiliations

Affiliations

  • 1 Department of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China.
  • 2 Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, National Center for Orthopaedics, Capital Medical University, Beijing, 100035, P. R. China.
  • 3 State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
  • 4 Department Electrical Engineering, City University of Hong Kong, 83 Tat Chee Ave, Kowloon Tong, 999077, Hong Kong SAR, P. R. China.
  • 5 Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, P. R. China.
  • 6 Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, National Center for Orthopaedics, Capital Medical University, Beijing, 100035, P. R. China. chendafu@jst-hosp.com.cn.
  • 7 State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China. liangrz@buct.edu.cn.
  • 8 Quzhou Institute for Innovation in Resource Chemical Engineering, Quzhou, 324000, P. R. China. liangrz@buct.edu.cn.
  • 9 Department of Cardiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, 323000, P. R. China. lvlingchun@medmail.com.cn.
  • # Contributed equally.
PMID: 41139778 DOI: 10.1186/s12951-025-03673-8
Abstract

Myocardial ischemia/reperfusion (I/R) injury represents a major global health concern, driven by excessive Reactive Oxygen Species (ROS), which closely correlates with subsequent myocardial infarction and fibrosis. Combining ROS scavenging with ischemic myocardium revascularization holds therapeutic promise. However, developing multifunctional therapeutic agents that can simultaneously scavenge ROS and promote angiogenesis remains unreported. Herein, we propose MgSrCeAl-layered double hydroxide (LDH) nanosheets as a multifunctional ROS scavenger and angiogenesis promoter for efficient myocardial I/R injury treatment. MgSrCeAl-LDH nanosheets not only exhibit exceptional hydroxyl radicals (·OH) and superoxide anions (·O2-) scavenging capabilities, which is 1.78 times and 1.61 times that of CeO2, respectively, but also respond to the ischemia-induced acidic microenvironment to release angiogenic Sr2+ with a concentration of 32.65 ppm (pH 5.0), which is conducive to efficient angiogenesis. Specifically, the ROS levels in I/R-injured myocardium decreased to 66.2% of its original value following intervention with MgSrCeAl-LDH nanosheets, while the vascular density in the peri-ischemic myocardium increased by approximately 3.6-fold. Ultimately, the infarcted myocardial area is reduced 60.9% compared to the group without MgSrCeAl-LDH intervention. Mechanistically, MgSrCeAl-LDH nanosheets alleviate myocardial infarction and fibrosis caused by I/R injury through activating PI3K/Akt pathway and inhibiting TGF-β pathway, ultimately improving cardiac function and inhibiting ventricular remodeling.

Keywords

Angiogenesis; Layered double hydroxides; Myocardial ischemia/reperfusion; Reactive oxygen species.

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