2. Academic Validation
  3. Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

Novel antineoplastic agents with efficacy against multidrug resistant tumor cells

  • Bioorg Med Chem Lett. 1998 Oct 6;8(19):2653-6. doi: 10.1016/s0960-894x(98)00477-6.
J C Medina 1,  B Shan,  H Beckmann,  R P Farrell,  D L Clark,  R M Learned,  D Roche,  A Li,  V Baichwal,  C Case,  P A Baeuerle,  T Rosen,  J C Jaen
Affiliations

Affiliation

  • 1 Tularik Inc., South San Francisco, CA 94080, USA.
PMID: 9873597 DOI: 10.1016/s0960-894x(98)00477-6
Abstract

A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated were the multidrug resistant (MDR) cell lines MCF-7/ADR and P388/ADR. The cytotoxic activity of members of this series of compounds was not affected by the multidrug resistant pump in MCF-7/ADR or P388/ADR cells.

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