1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. MCL0020

MCL0020 

目录号: HY-107627
产品使用指南

MCL0020 是一种有效的选择性黑素皮质素 MC4 受体拮抗剂,IC50 为 11.63 nM。MCL0020 具有剂量依赖性,可显著减轻束缚应激诱发的厌食症,且不影响食物摄入。

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MCL0020 Chemical Structure

MCL0020 Chemical Structure

CAS No. : 475498-26-1

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake[1].

IC50 & Target

IC50: 11.63 (MC4)

体外研究
(In Vitro)

MCL0020 inhibited [125I][N1e4, D-Phe7]α-MSH binding to membranes of COS-1 cells with IC50 values of 11.63[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

MCL0020 attenuates swim stress-induced anxiogeniclike behavior in light/dark exploration tests in mice[1].
MCL0020 significantly reverses stress-induced anorexia in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

609.72

Formula

C34H39N7O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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目录号:
HY-107627
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