2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphatase Apoptosis
  4. Microcystin-RR

Microcystin-RR  (Synonyms: Cyanoviridin RR)

目录号: HY-P0217
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摩尔计算器

Microcystin-RR (Cyanoviridin RR) 是一种有效的口服活性蛋白磷酸酶 (protein phosphatase) 抑制剂。Microcystin-RR 诱导细胞凋亡 (Apoptosis) 和小鼠肝脏的内质网应激。

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Custom Peptide Synthesis

Microcystin-RR Chemical Structure

Microcystin-RR Chemical Structure

CAS No. : 111755-37-4

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规格 价格 是否有货 数量
100 μg ￥2500
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Microcystin-RR 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Microcystin-RR (Cyanoviridin RR) is a potent and orally active protein phosphatase inhibitor. Microcystin-RR induces Apoptosis and ER stress in mice liver[1][2].

体内研究
(In Vivo)

Microcystin-RR (0、4..6、23、46、93、186 µg/mL；灌胃；每日一次，连续 7 天) 在小鼠肝脏中以剂量依赖性方式诱导细胞凋亡并增加 Bax、p53 的表达，降低 Bcl-2 的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-22 g, male ICR mice[2]
Dosage: 0, 4..6, 23, 46, 93, 186 µg/mL
Administration: Gavage; daily for 7 days
Result: Induced obvious apoptosis in mice liver with the percentage of apoptotic cells were 10.46, 12.6, 12.7, 13.3, 28.5, and 37.5% for 0, 4..6, 23, 46, 93, 186 µg/mL, respectively; increased the expression of Bax,p53, decreased the expression of Bcl-2 in a dose-dependent manner in mice liver.
分子量

1038.20

Formula

C49H75N13O12
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

Microcystin-RR 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Microcystin-RR111755-37-4Cyanoviridin RRPhosphataseApoptosisorally activeapoptosisER stressBaxp53Bcl-2Inhibitorinhibitorinhibit

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