2. PROTAC NF-κB Apoptosis
  3. Ligands for Target Protein for PROTAC NF-κB Apoptosis
  4. MMH-165-26

MMH-165-26 是 RelA/p65 蛋白的配体。MMH-165-26 降低 RelA/p65 的表达并在 MEC-1 (LC50 = 0.37 μM) 细胞中具有显著的细胞毒性。MMH-165-26 可用于合成 PROTAC，如 JP-163-16 (HY-174864)。

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MMH-165-26

MMH-165-26 Chemical Structure

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MMH-165-26 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMH-165-26 is a ligand for RelA/p65. MMH-165-26 reduces the expression of RelA/p65 and has significant cytotoxicity in MEC-1 (LC50 = 0.37 μM) cells. MMH-165-26 can be used for synthesizing PROTACs such as JP-163-16 (HY-174864)[1].

IC50 & Target[1]

p65

 

体外研究
(In Vitro)

MMH-165-26 (Compound 20d) (0.1-5 μM，48 小时) 显著抑制 MDA-MB-231 (LC50 = 6.7 μM) 细胞的生长，并以蛋白酶体依赖的方式降低 RelA/p65 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MMH-165-26 相关抗体:

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 1, 5 μM
Incubation Time: 48 h
Result: Significantly increased the apoptosis rate of cells.
分子量

422.48

Formula

C23H26N4O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MMH-165-26 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMH-165-26Ligands for Target Protein for PROTACNF-κBApoptosisTarget Protein-binding MoietyNuclear factor-κBNuclear factor-kappaBRelA/p65PROTACInhibitorinhibitorinhibit

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产品名称：
MMH-165-26
目录号：
HY-174865
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