2. Metabolic Enzyme/Protease
  3. MMP
  4. MMP-13-IN-1

MMP-13-IN-1 是一种高效的，选择性的 MMP-13 抑制剂，其 IC50 值为 16 nM。 MMP-13-IN-1 可用于动脉粥样硬化研究。

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MMP-13-IN-1 Chemical Structure

MMP-13-IN-1 Chemical Structure

CAS No. : 2925249-49-4

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MMP-13-IN-1 相关抗体

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查看 MMP 亚型特异性产品:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMP-13-IN-1 is a potent and selective inhibitor of MMP-13 with a IC50 value of 16 nM. MMP-13-in-1 can be used for atherosclerosis research[1].

IC50 & Target[1]

MMP13

16 nM (IC50)

体内研究
(In Vivo)

MMP-13-IN-1 (compound 5j) (2.5 mg/kg; 使用放射性示踪剂前 15 分钟静脉注射) 在 ApoE−/− 小鼠模型中表现出代谢器官摄取低，心肌放射性保留最少，肾脏清除率高，代谢稳定性高的特点[1]。
MMP-13-IN-1 (compound 5j) (2.5 mg/kg; 使用放射性示踪剂前 15 分钟静脉注射) 显示最高的总体摄取和 ORO 阳性区域的最大共定位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ApoE−/− mice models[1]
Dosage: 2.5 mg/kg
Administration: Intravenous injection (i.v.); intravenously administered 15 min prior to the radiotracer
Result: Blood radioactivity continued to decrease between 30 and 60 min and stabilized thereafter.
Displayed a significant reduction in liver uptake.
Relatively low levels of radioactivity were observed in all other measured organs except for the pancreas and spleen.
Resulted in a 23% decrease in aortic plaque uptake , indicating an extent of saturable binding.
分子量

391.34

Formula

C19H16F3N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MMP-13-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMP-13-IN-12925249-49-4MMPMatrix metalloproteinasesatherosclerosisApoE?/? miceradiotracerInhibitorinhibitorinhibit

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产品名称：
MMP-13-IN-1
目录号：
HY-154868
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