1. Autophagy
  2. Autophagy
  3. MPM-1

MPM-1 是海洋生物 Eusynstyelamides 模拟物,是一种有效的抗癌剂。MPM-1 可通过诱导坏死样死亡,在体外快速杀死癌细胞。MPM-1具有诱导免疫原性细胞死亡的能力。MPM-1在癌细胞中干扰细胞自噬 (autophagy) 和溶酶体膨胀。

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MPM-1 Chemical Structure

MPM-1 Chemical Structure

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MPM-1, a marine Eusynstyelamides mimic, is a potent anticancer agent. MPM-1 can rapidly kill cancer cells in vitro by inducing a necrosis-like death. MPM-1 has the ability to induce immunogenic cell death. MPM-1 causes perturbation of autophagy and lysosomal swelling in cancer cells[1].

IC50 & Target

Autophagy[1]

体外研究
(In Vitro)

MPM-1 (0-50 μM; 4 h) has cytotoxicity against various human cancer cell lines[1].
MPM-1 (8.5 and 17.0 μM; 1-6 h) causes perturbation of autophagy and lysosomal swelling[1].
MPM-1 induces the release and exposure of damage-associated molecular patterns (DAMPs) related to immunogenic cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Jurkat, Ramos, HSC-3, MCF-7, A375, et al.
Concentration: 0-50 μM
Incubation Time: 4 h
Result: Exhibited potent cytotoxicity against Jurkat, Ramos, HSC-3, MCF-7, A375 with IC50s of 6.62 ± 1.60 μM, 7.53 ± 2.01 μM, 8.53 ± 0.57 μM, 14.06 ± 2.71 μM, 14.52 ± 0.22 μM, respectively.

Immunofluorescence[1]

Cell Line: HSC-3
Concentration: 8.5 and 17.0 μM
Incubation Time: 1, 2, 4 and 6 h
Result: Significantly increased the total number of autophagy markers p62 (substrate of autophagy) and LC3B.
Caused the distribution of the lysotracker dye more diffuse and less intense, indicating that lysosomal morphology was influenced.

Western Blot Analysis[1]

Cell Line: Ramos and HSC-3
Concentration: 8.5 μM for Romas and 17.0 μM for HSC-3
Incubation Time: 0.5, 1, 2, 3 and 4 h
Result: Increased the release of high mobility group box 1 (HMGB1) from cells.
分子量

734.73

Formula

C34H44F6N4O7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

MPM-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MPM-1
目录号:
HY-151503
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