2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK Epigenetics Stem Cell/Wnt Apoptosis
  3. EGFR JAK STAT Apoptosis
  4. MRC-G-001

MRC-G-001 是一种 Genipin (HY-17389) 衍生物，其对于 A549 癌症细胞的 IC50 值为 117 μM。MRC-G-001 能抑制 EGFR、JAK1 和 STAT3 的磷酸化，并调节与上皮-间质转化 (EMT) 相关的蛋白质表达，从而抑制细胞迁移和侵袭。MRC-G-001 可诱导细胞周期停滞和细胞凋亡 (apoptosis)。MRC-G-001 可用于非小细胞肺癌等癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MRC-G-001

MRC-G-001 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MRC-G-001 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRC-G-001 is a Genipin (HY-17389) derivative with an IC50 of 117 μM against A549 cancer cells. MRC-G-001 inhibits the phosphorylation of EGFR, JAK1, and STAT3, and modulates epithelial-mesenchymal transition (EMT)-related protein expression, thereby attenuating cell migration and invasion. MRC-G-001 induces cell cycle arrest and cell apoptosis. MRC-G-001 can be used for the study of cancers such as non-small-cell lung cancer[1].

IC50 & Target[1]

JAK1

 

STAT3

 

体外研究
(In Vitro)

MRC-G-001 (Compound 2b) (0-500 μM,24-72 h) 可使 A549 的细胞活力呈剂量和时间依赖性降低，与 Genipin 相比具有更强的细胞毒性[1]。
MRC-G-001 (0-100 μM, 7 days) 能有效抑制 A549 细胞的长期增殖能力[1]。
MRC-G-001 (0-250 μM) 可强效将 A549 细胞周期阻滞在 G1/S 期[1]。
MRC-G-001 (0-250 μM, 24 h) 比 Genipin 更大程度上诱导了 A549 细胞凋亡[1]。
MRC-G-001 (0-250 μM, 24 h) 能在 A549 细胞中有效抑制 EGFR 和 JAK1/STAT3 信号通路[1]。
MRC-G-001 (100 μM, 0-24 h) 可通过干扰 TGF-β 诱导的 EMT 信号通路抑制 A549 细胞的迁移和侵袭[1]。
MRC-G-001 在 A549 细胞中不抑制 ATP 依赖的 EGFR 激酶活性，但会结合 EGFR 的胞外域 (III 结构域)，提示其可能通过一种替代性的非 ATP 依赖机制发挥作用，该机制或许与干扰 EGF 结合有关[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MRC-G-001 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0, 62.5, 125 and 250 μM
Incubation Time: 24 h
Result: Decreased the phosphorylated p-Rb (Ser807/811) level.
Increased the level of cleaved caspase-3, cleaved caspase-8, and cleaved caspase-9.
Resulted in effective suppression of p-EGFR, p-JAK1, and p-STAT3 protein expression levels.
Did not alter UCP2 expression at lower concentrations, but slightly decreased its level at 250 μM.

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 0, 62.5, 125 and 250 μM
Incubation Time: 24 h
Result: Led to a dose-dependent increase in both early apoptotic and late apoptotic populations.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Led to an upregulation of E-cadherin and downregulation of N-cadherin, MMP9, Snail, and RhoA.
Inhibited the phosphorylation of SMAD2 and SMAD3, while SMAD4 protein levels remained largely unchanged.
分子量

357.44

Formula

C21H27NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MRC-G-001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRC-G-001EGFRJAKSTATApoptosisEpidermal growth factor receptorErbB-1HER1Janus kinaseGenipin derivativesA549 Cancer cellsInvasionMigrationEGFInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MRC-G-001
目录号：
HY-175009
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z