1. GPCR/G Protein
  2. Adenosine Receptor
  3. MRE3008F20

MRE3008F20 是一种高效的、高选择性的和具有放射性的腺苷 A3 受体 (AA3R) 拮抗剂 (Ki=1.8 nM)。MRE3008F20 在静止的淋巴细胞中,能有效拮抗 Cl-IB-MECA 诱导的 cAMP 的产生,其 IC50 值为 5 nM。MRE3008F20 可用于 AA3R 的研究。

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MRE3008F20 Chemical Structure

MRE3008F20 Chemical Structure

CAS No. : 252979-43-4

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R[1][2].

IC50 & Target

IC50 : 5 nM (AA3R)[1]

体外研究
(In Vitro)

MRE3008F20 (0.1-100 nM) antagonizes 100 nM Cl-IB-MECA-induced inhibition of cAMP levels in resting human lymphocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human lymphocytes
Concentration: 0.1-100 nM
Incubation Time:
Result: Antagonized 100 nM Cl-IB-MECA-induced inhibition of cAMP levels with an IC50 of 5.0 nM in resting Lymphocytes.
分子量

432.44

Formula

C21H20N8O3

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

参考文献

MRE3008F20 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
MRE3008F20
目录号:
HY-103178
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