1. GPCR/G Protein
  2. P2Y Receptor
  3. MRS2179 tetrasodium

MRS2179 tetrasodium 是一种竞争性 P2Y1 受体拮抗剂,对火鸡 P2Y1 受体的 Kb 值为 102 nM,pA2 为 6.99。MRS2179 tetrasodium 对 P2Y1 的选择性高于 P2X1 (IC50=1.15 µM)、P2X3 (12.9 µM)、P2X2、P2X4、P2Y2、P2Y4 和 P2Y6 受体。MRS2179 tetrasodium 抑制血小板聚集。

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MRS2179 tetrasodium Chemical Structure

MRS2179 tetrasodium Chemical Structure

CAS No. : 1454889-37-2

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生物活性

MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a Kb of 102 nM and a pA2 of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC50=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors[1][2]. MRS2179 tetrasodium inhibits platelet aggregation[3].

体内研究
(In Vivo)

MRS2179 (50 mg/kg; i.p.) prolongs the bleeding time[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CL57BLr6 mice[3]
Dosage: 50 mg/kg
Administration: Injection into the jugular vein of mice
Result: The bleeding time, which reflects in vivo primary haemostasis, was significantly prolonged in MRS2179-treated mice, 30 s after injection of MRS2179.
分子量

513.16

Formula

C11H13N5Na4O9P2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
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