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  3. MT1

MT1 

目录号: HY-111976
产品使用指南

MT1 是 BET bromodomains 的化学探针,其对BRD4(1) 的 IC50 值为 0.789 nM。

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MT1 Chemical Structure

MT1 Chemical Structure

CAS No. : 2060573-82-0

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Description

MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].

In Vitro

MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1].

Western Blot Analysis[1]

Cell Line: MV4;11 cells[1].
Concentration: 100 nM.
Incubation Time: 24 h.
Result: Significant apoptosis was observed by caspase-3 and PARP cleavage after treatment.
In Vivo

MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1].
MT1 exhibits terminal t1/2 of 2.70 h in mice[1].

Animal Model: Leukemia xenograft models[1].
Dosage: 44.2 and 22.1 µmol/kg.
Administration: Intraperitoneally for 14 subsequent days.
Result: Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1.
Molecular Weight

1134.20

Formula

C₅₄H₆₆Cl₂N₁₀O₉S₂

CAS No.

2060573-82-0

SMILES

CC1=NN=C2N1C3=C(C(C4=CC=C(C=C4)Cl)=N[C@H]2CC(NCCOCCOCCOCCOCCOCCOCCOCCNC(C[C@@H]5N=C(C6=C(N7C5=NN=C7C)SC(C)=C6C)C8=CC=C(C=C8)Cl)=O)=O)C(C)=C(C)S3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MT1MT 1MT-1Epigenetic Reader Domaincaspase-3PARPleukemiaJQ1Inhibitorinhibitorinhibit

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MT1
目录号:
HY-111976
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