2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. MY33-3

MY33-3 是一种有效和选择性的蛋白酪氨酸磷酸酶 RPTPβ/ζ 抑制剂，IC50 值为 ~0.1 μM。MY33-3 还抑制 PTP-1B (IC50 ~0.7 μM)。MY33-3 可以减少乙醇消耗并缓解 Sevoflurane 引起的神经炎症和认知功能障碍。

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MY33-3 Chemical Structure

MY33-3 Chemical Structure

CAS No. : 2204280-41-9

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规格 价格 是否有货 数量
1 mg ￥1454
In-stock
5 mg ￥3200
In-stock
10 mg ￥5100
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of MY33-3:

MY33-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MY33-3 is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, with an IC50 of ~0.1 μM. MY33-3 also inhibits PTP-1B (IC50 ~0.7 μM). MY33-3 can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction[1][2][3].

IC50 & Target

IC50: 0.1 μM (RPTPβ/ζ), 0.7 μM (PTP-1B)[1]
体外研究
(In Vitro)

MY33-3 (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells[1].
MY33-3 (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MY33-3 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 1 μM
Incubation Time: Pretreated for 5 min and co-treated for 15 min
Result: Decreased the Ethanol-induced activation of TrkA and ALK.
None of the treatments significantly changed total TrkA or total ALK protein levels.
体内研究
(In Vivo)

MY33-3 (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 reduces preference for the ethanol solution on day 3[1].
MY33-3 (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (8-10 weeks of age) are received two-bottle drinking in the dark (DID) procedure using 20% ethanol[1]
Dosage: 60 mg/kg
Administration: P.o. 1 hour before the drinking session in the DID test on days 3 and 4
Result: Reduced ethanol consumption when comparing day 2 with day 3.
Showed a reduced preference for the ethanol solution.
Not affected total fluid consumption.
分子量

397.40

Formula

C16H13F6NS2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (25.16 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5164 mL 12.5818 mL 25.1636 mL
5 mM 0.5033 mL 2.5164 mL 5.0327 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MY33-3 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5164 mL 12.5818 mL 25.1636 mL 62.9089 mL
5 mM 0.5033 mL 2.5164 mL 5.0327 mL 12.5818 mL
10 mM 0.2516 mL 1.2582 mL 2.5164 mL 6.2909 mL
15 mM 0.1678 mL 0.8388 mL 1.6776 mL 4.1939 mL
20 mM 0.1258 mL 0.6291 mL 1.2582 mL 3.1454 mL
25 mM 0.1007 mL 0.5033 mL 1.0065 mL 2.5164 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MY33-32204280-41-9PhosphataseRPTPβ/ζPTP-1BethanolneuroinflammationcognitiveInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-123966
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