1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. N3-PEG5-aldehyde

N3-PEG5-aldehyde 是一种可降解 (cleavable) 的含 5 个单元 PEG 的 ADC linker,可用于合成抗体偶联活性分子 (ADC)。N3-PEG5-aldehyde 是一种点击化学试剂。它含有 Azide 基团,可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应(CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。

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N3-PEG5-aldehyde Chemical Structure

N3-PEG5-aldehyde Chemical Structure

CAS No. : 2566404-73-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N3-PEG5-aldehyde is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. N3-PEG5-aldehyde is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

Cleavable Linker

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

438.47

Formula

C20H30N4O7

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

N3-PEG5-aldehyde 相关分类

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