1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Naftopidil hydrochloride

Naftopidil hydrochloride (Synonyms: KT-611 hydrochloride; BM-15275 hydrochloride)

目录号: HY-B0391B
产品使用指南

Naftopidil hydrochloride (KT-611 hydrochloride) 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂,具有抗增殖作用。Naftopidil dihydrochloride 可用于前列腺增生的研究。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Naftopidil hydrochloride Chemical Structure

Naftopidil hydrochloride Chemical Structure

CAS No. : 1164469-60-6

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Naftopidil hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Naftopidil hydrochloride:

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Naftopidil hydrochloride (KT-611 hydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1].

In Vitro

Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[1].
Naftopidil hydrochloride (10 μM for PCa cells; 0.1-10 μM for PrSC) shows growth inhibitory effects on PrSC and PCa cells[1].
Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[1].

Cell Proliferation Assay[1]

Cell Line: PCa cells, PrSC
Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC)
Incubation Time: 3 days
Result: Exhibited growth inhibitory effects on PCa cells, PrSC in dose-dependent manners.

Western Blot Analysis[1]

Cell Line: PCa cells, PrSC
Concentration: 50 μM (E9 cells), 25 μM (PrSC)
Incubation Time: 48 hours
Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
In Vivo

Naftopidil hydrochloride (10 mg/kg; p.o; daily, for 28 days) decreases microvessel density (MVD) in E9 + PrSC tumors mice model[1].

Animal Model: Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1]
Dosage: 10 mg/kg
Administration: Oral administration, daily, for 28 days
Result: Decrease tumor weights.
Molecular Weight

428.95

Formula

C₂₄H₂₉ClN₂O₃

CAS No.

1164469-60-6

中文名称

萘哌地尔盐酸盐

SMILES

[H]Cl.OC(CN1CCN(C(C=CC=C2)=C2OC)CC1)COC3=CC=CC4=CC=CC=C34

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NaftopidilKT-611BM-15275KT611KT 611BM15275BM 15275Adrenergic ReceptorBeta ReceptorprostatehyperplasiacanineprostaticpressureInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Naftopidil hydrochloride
目录号:
HY-B0391B
需求量: