2. Apoptosis
  3. Apoptosis
  4. Neoechinulin A

Neoechinulin A 是一种异戊烯基吲哚生物碱，具有清除、神经营养因子样和抗凋亡活性。Neoechinulin A 诱导小鼠记忆改善和抗抑郁样作用。

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Neoechinulin A Chemical Structure

Neoechinulin A Chemical Structure

CAS No. : 51551-29-2

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Neoechinulin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice[1][2].

体外研究
(In Vitro)

Neoechinulin A (RAW264.7 macrophages; 3 hours; cells then stimulated with LPS (1 μg/mL) for 18 hours) suppresses PGE2, TNF-α, and IL-1β production in a dose-dependent manner[2].
Neoechinulin A can suppress the production of pro-inflammatory mediators and cytokines including NO, PGE2, TNF-α, and IL-1β. Further, it reduced the expression of iNOS and COX-2 in LPS-stimulated RAW264.7 macrophages by inhibiting the NF-κB and p38 MAPK signaling pathways[2].
Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neoechinulin A 相关抗体:
体内研究
(In Vivo)

In the Y-maze test, the intracerebroventicular (i.c.v.) administration of LPS (10 μg/mouse) significantly decreased spontaneous alternation behavior, which was prevented by the prior administration of neoechinulin A (300ng/mouse, i.c.v.)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

323.39

Formula

C19H21N3O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

fungus Aspergillus sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥98.0%

COA (273 KB)

产品使用指南 (1538 KB)
参考文献

Neoechinulin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neoechinulin A51551-29-2Apoptosisalkaloidmemoryimprovementsantidepressantinflammationpro-inflammatoryRAW264.7macrophagesInhibitorinhibitorinhibit

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