Nerolidol-d₄  (Synonyms: 橙花叔醇-d₄)

Nerolidol-d₄ is deuterated labeled Nerolidol (HY-N1944). Nerolidol has multiple natural membrane activities, possesses anti-cancer, anti-inflammatory, antibacterial and anti-insect activity. Nerolidol Suppresses parasitic activity, suppresses bloodsucking diseases, bloodworm diseases, and other diseases. Nerolidol can protect the cells from lipid and protein properties, damage to DNA, and protect the cells from damage^[1][2][3].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Nerolidol 表现出有效的抗氧化特性，可保护细胞免受脂质、蛋白质和 DNA 的氧化损伤，从而平衡 ROS 的影响^[3]。
Nerolidol 对金黄色葡萄球菌 FDA 209P 表现出有效的抗菌活性，包括 14 种甲氧西林敏感的金黄色葡萄球菌 (MSSA) 和 20 株耐甲氧西林金黄色葡萄球菌 (MRSA)，MIC 值为 512 至 1024+ μg/mL^[3]。
Nerolidol 对多种病原体表现出抗生物膜活性^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nerolidol (0.5%–2%) 还对引起皮肤癣菌病的石膏小孢子菌具有很强的抗真菌作用，这是一种角化组织的浅表感染，包括头发、指甲和皮肤角质层^[3]。
Nerolidol (25-75 mg/kg；腹腔注射；单剂量）显示小鼠海马体对神经元细胞氧化应激的神经保护作用^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

226.39

C₁₅H₂₂D₄O

7212-44-4

橙花叔醇-d₄

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Nogueira Neto JD, et al. Antioxidant effects of nerolidol in mice hippocampus after open field test. Neurochem Res. 2013 Sep;38(9):1861-70.  [Content Brief]

  [3]. Chan WK, et al. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016 Apr 28;21(5):529.  [Content Brief]

  [4]. Nerolidol, et al. In vitro antileishmanial and cytotoxic activities of nerolidol are associated with changes in plasma membrane dynamics. Biochim Biophys Acta Biomembr. 2019 Jun 1;1861(6):1049-1056.  [Content Brief]