Nerolidol-d₄  (Synonyms: 橙花叔醇-d₄)

Nerolidol-d₄ is deuterated labeled Tenuazonic acid (HY-N6715). Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate^[1]. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D₁ protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor^[2].

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱^[1]。
Nerolidol 表现出有效的抗氧化特性，可保护细胞免受脂质、蛋白质和 DNA 的氧化损伤，从而平衡 ROS 的影响^[3]。
Nerolidol 对金黄色葡萄球菌 FDA 209P 表现出有效的抗菌活性，包括 14 种甲氧西林敏感的金黄色葡萄球菌 (MSSA) 和 20 株耐甲氧西林金黄色葡萄球菌 (MRSA)，MIC 值为 512 至 1024+ μg/mL^[3]。
Nerolidol 对多种病原体表现出抗生物膜活性^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nerolidol (0.5%–2%) 还对引起皮肤癣菌病的石膏小孢子菌具有很强的抗真菌作用，这是一种角化组织的浅表感染，包括头发、指甲和皮肤角质层^[3]。
Nerolidol (25-75 mg/kg；腹腔注射；单剂量）显示小鼠海马体对神经元细胞氧化应激的神经保护作用^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

226.39

C₁₅H₂₂D₄O

橙花叔醇-d₄

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Nogueira Neto JD, et al. Antioxidant effects of nerolidol in mice hippocampus after open field test. Neurochem Res. 2013 Sep;38(9):1861-70.  [Content Brief]

  [3]. Chan WK, et al. Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities. Molecules. 2016 Apr 28;21(5):529.  [Content Brief]

  [4]. Nerolidol, et al. In vitro antileishmanial and cytotoxic activities of nerolidol are associated with changes in plasma membrane dynamics. Biochim Biophys Acta Biomembr. 2019 Jun 1;1861(6):1049-1056.  [Content Brief]