1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. NH2-MPAA-NODA

NH2-MPAA-NODA 是一种基于硝基的可光裂解的 linker,它有一个 NODA 修饰单元和一个 MPAA 主链。NH2-MPAA-NODA 可以通过标记 18F-氟化物来用作放射性标签。

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NH2-MPAA-NODA Chemical Structure

NH2-MPAA-NODA Chemical Structure

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

生物活性

NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone[1]. NH2-MPAA-NODA can be used as a radiolabel by labeling with 18F-fluoride.

IC50 & Target

IC50: Nitroveratryl-based photocleavable linker

体外研究
(In Vitro)

NH2-MPAA-NODA contains the 1,4,7-triazacyclononane-1,4-diacetate (NODA) motif with a methyl phenyl acetic acid (MPAA) backbone, and it has enough ability to form stable Al18F-chelates. The organ of luoroaluminates are easily accessible from the reaction of 1 and AlF3.
NH2-MPAA-NODA can be conjugated to some inhibitors/antagonists labeled with 18F for PET imaging of targeting tumors. It also can be used as a radiolabel of peptides[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

435.52

Formula

C21H33N5O5

性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥97.0%

NH2-MPAA-NODA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
NH2-MPAA-NODA
目录号:
HY-135859
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