2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. NK224

NK224 是一种靶向人 PD-L1 的基于肽的放射性示踪剂，通过 NOTA 螯合剂实现双核素（68Ga 和 18F）标记兼容性。NK224 对 PD-L1 表现出高结合亲和力，其 IC50 值为 2.45 nM。NK224 可视化患者体内肿瘤异质性，并动态监测免疫治疗期间 PD-L1 靶点占用情况。NK224 可用于非小细胞肺癌 (NSCLC) 研究。

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Custom Peptide Synthesis

NK224

NK224 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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NK224 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide (68Ga and 18F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC50 value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC)[1].

分子量

2241.48

Formula

C104H145N25O29S
Sequence

cyclo-(Ac-Tyr-NMeAla-Asn-Pro-His-Glu-Hyp-Trp-Ser-{TrpNHOAc}-NMeNle-NMeNle-Lys-Cys)-Gly-NH2-NOTA
Sequence Shortening

cyclo-{Ac-Y-{NMeAla}-NPHE-{Hyp}--{TrpNHOAc}-WS-{NMeNle-NMeNle}-KC}-G-NH2-NOTA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NK224 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NK224NK 224NK-224PD-1/PD-L1PD-1/Programmed death-ligand 1PD-L1non-small cell lung cancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-P10978
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