1. Immunology/Inflammation
  2. NTPDase
  3. NTPDase-IN-1

NTPDase-IN-1 (化合物 5a) 是一种具有选择性的 NTPDase 抑制剂,其对 h-NTPDase-1/-2/-8IC50 值分别为 0.05, 0.23 和 0.54 µM。NTPDase-IN-1 可非竞争性地抑制 h-NTPDase-1/-2,其对 h-NTPDase-1Km 值为 21 µM。NTPDase-IN-1 可用于癌症、免疫学疾病以及细菌感染的研究。

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NTPDase-IN-1 Chemical Structure

NTPDase-IN-1 Chemical Structure

CAS No. : 2962812-29-7

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

NTPDase-IN-1 (compound 5a) is a selective NTPDase inhibitor with IC50s of 0.05, 0.23 and 0.54 µM for h-NTPDase-1/-2/-8, respectively. NTPDase-IN-1 non-competitively inhibits h-NTPDase-1/-2 with a Km of 21 µM for h-NTPDase-1. NTPDase-IN-1 can be used in studies of cancer, immunologic disorders as well as bacterial infections[1].

IC50 & Target

h-NTPDase-1

0.05 μM (IC50)

h-NTPDase-2

0.23 μM (IC50)

h-NTPDase-8

0.54 μM (IC50)

h-NTPDase-3

>100 μM (IC50)

分子量

363.54

Formula

C18H25N3OS2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
NTPDase-IN-1
目录号:
HY-143287
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