2. Apoptosis Metabolic Enzyme/Protease
  3. Ferroptosis Mitochondrial Metabolism Glutathione Peroxidase Transferrin Receptor MMP Dihydroorotate Dehydrogenase
  4. OART

OART  (Synonyms: Oxaliplatin-artesunate)

目录号: HY-177483
产品使用指南 技术支持

OART (Oxaliplatin-artesunate) 是一种铁死亡 (ferroptosis) 诱导剂。OART 显著抑制肿瘤细胞增殖。OART 通过破坏谷胱甘肽介导的铁死亡防御系统并增强铁依赖的 Fenton 反应，诱导细胞质和线粒体 LPO 促进肿瘤铁死亡。OART 增强肿瘤免疫原性，将肿瘤环境从免疫抑制转变为免疫敏感。OART 在荷瘤小鼠模型中具有很强的肿瘤消退作用。OART 可用于癌症免疫治疗研究。

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OART

OART Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

OART 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research[1].

分子量

797.71

Formula

C27H42N2O13Pt+
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OART 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OARTOxaliplatin-artesunateFerroptosisMitochondrial MetabolismGlutathione PeroxidaseTransferrin ReceptorMMPDihydroorotate DehydrogenaseTfRCD71Matrix metalloproteinasesDHODHCytoplasmicMitochondrialLPO4T1 cellsB16F10 cellsRenca cellsHUVECGlutathioneFenton reactionTumor regressionCancer immunotherapyTumor-bearing mouse modelsInhibitorinhibitorinhibit

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