2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. Somatostatin Receptor Apoptosis
  4. Octreotide dihydrochloride

Octreotide dihydrochloride  (Synonyms: SMS 201-995 dihydrochloride)

目录号: HY-P0036A
产品使用指南 技术支持

Octreotide (SMS 201-995) hydrochloride 是一种生长抑素受体 (somatostatin receptor) 激动剂，合成八肽生长抑素类似物。Octreotide hydrochloride 可与生长抑素受体 (somatostatin receptor) 结合，主要有 2，3，5 亚型，可增强 Gi 活性，降低胞内 cAMP 的产生。具有抗肿瘤活性，可介导细胞凋亡 (apoptosis)，也可用于肢端肥大症的疾病研究。

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Octreotide dihydrochloride

Octreotide dihydrochloride Chemical Structure

CAS No. : 1607842-55-6

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Octreotide dihydrochloride 的其他形式现货产品:

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Octreotide dihydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Octreotide (SMS 201-995) hydrochloride is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide hydrochloride can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide hydrochloride increases Gi activity and reduces intracellular cAMP production. Octreotide hydrochloride has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].

体外研究
(In Vitro)

Octreotide hydrochloride (10-8 mM，6 小时) 诱导磷酸化糖原合成酶激酶 3β (GSK3β) 磷酸化并增加糖原合成酶 (GS) 活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Octreotide dihydrochloride 相关抗体:

Western Blot Analysis[3]

Cell Line: Human hepatoblastoma HepG2 cell line
Concentration: 10‑8mM
Incubation Time: 6 hours
Result: Increased the protein expression levels of phosphorylated‑Akt and GSK3β by 140.8% and 12.2%, respectively and the mRNA level of GS also increased.
体内研究
(In Vivo)

Octreotide hydrochloride (皮下注射，30 mg/kg，一次，持续 8 周) 可显著抑制肿瘤生长，且对体重无影响[1]。
Octreotide hydrochloride (肌内注射，60 mg/kg，每 21 天一次，持续 42 天) 可抑制患有四肢骨肉瘤的犬血清胰岛素样生长因子 (IGF-I) 水平，且无毒性[2]。
Octreotide hydrochloride (皮下注射，40 μg/kg，每 12 小时一次，连续 8 天) 可改善肥胖雄性 Sprague-Dawley (SD) 大鼠的肝糖原合成[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (nu/nu Balbc-A weighing 19-22 g)[1]
Dosage: 30 mg/kg
Administration: Subcutaneous injection; once; 8 weeks
Result: Showed that the average volume of tumors treated was 25.8% of the control group and no effect on body weight.
Animal Model: Dogs with appendicular OSA[2]
Dosage: 60 mg/kg
Administration: Intramuscular injection; Every 21 days; 42 days
Result: Resulted in a 43% decrease in mean serum IGF-I compared with mean baseline concentrations.
Animal Model: Male Sprague‑Dawley (SD) rats (3 weeks; 40-60 g)[3]
Dosage: 40 μg/kg
Administration: Subcutaneous injection; Every 12 hours; 8 days
Result: Significantly improved fat deposition and reduced lipid infiltration.
分子量

1092.16

Formula

C49H68Cl2N10O10S2
CAS 号
Sequence

{d-Phe}-cyclo(Cys-Phe-{d-Trp}-Lys-Thr-Cys-{d-Threoninol}) (Disulfide bridge: Cys2-Cys7)
Sequence Shortening

{d-Phe}-cyclo(CF{d-Trp}-KTC)-{d-Threoninol} (Disulfide bridge: Cys2-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Octreotide dihydrochloride 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Octreotide1607842-55-6SMS 201-995Somatostatin ReceptorApoptosisSSTRsSSTRSomatostatin receptor agonistAcromegalyCancerInhibitorinhibitorinhibit

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