2. Metabolic Enzyme/Protease
  3. Neprilysin
  4. Opiorphin

Opiorphin 是一种阿片类肽，是一种强效的人脑啡肽失活锌异肽酶抑制剂。Opiorphin 抑制两种脑啡肽分解外酶，人中性外肽内源性肽酶 hNEP (EC 3.4.24.11)和人外氨基肽酶 hAP-N (EC 3.4.11.2)。Opiorphin 通过激活内源性阿片依赖性传递显示出强大的镇痛活性。

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Custom Peptide Synthesis

Opiorphin Chemical Structure

Opiorphin Chemical Structure

CAS No. : 864084-88-8

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规格 价格 是否有货 数量
5 mg ￥293
In-stock
10 mg ￥440
In-stock
25 mg ￥880
In-stock
50 mg ￥1440
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Opiorphin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2].

体外研究
(In Vitro)

Opiorphin (1-100 μM; the mouse isolated colon) causes contractile effects in mouse distal colon in a concentration-dependent manner and enhances the contractile response induced by Met-enkephalin[1].
Opiorphin (0-50 μM; hNEP or hAP-N transformed HEK293 cell line) is a dual inhibitor of enkephalin-degrading hNEP and hAP-N in vitro. Opiorphin inhibits Mca-BK2 endoproteolysis by the cell-surface recombinant hNEP with an IC50 value of 33 μM. and inhibits the Ala-pNA cleavage by hAP-N with an IC50 value of 65 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Opiorphin 相关抗体:
体内研究
(In Vivo)

Opiorphin (1.25-10 μg/kg; ICV; 0-60 min; male Kunming mice) induces potent analgesic effect in a dose- and time-dependent manner (ED50=3.22 μg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Kunming mice[1]
Dosage: 1.25, 2.5, 5, 10 μg/kg
Administration: Intracerebroventrical injection; post-drug latency measurements were performed at 5, 10, 20, 30, 40, 50 and 60 min
Result: Had the percentage change of tail withdrawal latency (TWL) at 10 min after i.c.v. administration of 1.25-10 mg/kg was 28.90%, 44.37%, 56.43% and 91.899.79%, respectively.
分子量

692.77

Formula

C29H48N12O8
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

QRFSR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 100 mg/mL (144.35 mM)

DMSO 中的溶解度 : 100 mg/mL (144.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4435 mL 7.2174 mL 14.4348 mL
5 mM 0.2887 mL 1.4435 mL 2.8870 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 98.83%

COA (193 KB) LCMS (87 KB)

产品使用指南 (1538 KB)
参考文献

Opiorphin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.4435 mL 7.2174 mL 14.4348 mL 36.0870 mL
5 mM 0.2887 mL 1.4435 mL 2.8870 mL 7.2174 mL
10 mM 0.1443 mL 0.7217 mL 1.4435 mL 3.6087 mL
15 mM 0.0962 mL 0.4812 mL 0.9623 mL 2.4058 mL
20 mM 0.0722 mL 0.3609 mL 0.7217 mL 1.8044 mL
25 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.4435 mL
30 mM 0.0481 mL 0.2406 mL 0.4812 mL 1.2029 mL
40 mM 0.0361 mL 0.1804 mL 0.3609 mL 0.9022 mL
50 mM 0.0289 mL 0.1443 mL 0.2887 mL 0.7217 mL
60 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6015 mL
80 mM 0.0180 mL 0.0902 mL 0.1804 mL 0.4511 mL
100 mM 0.0144 mL 0.0722 mL 0.1443 mL 0.3609 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Opiorphin864084-88-8NeprilysinNeutral endopeptidaseNEPCluster of differentiation 10CD10opioid peptideenkephalin-catabolizing ectoenzymesanalgesicendogenous opioidInhibitorinhibitorinhibit

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