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  3. Org-12962 hydrochloride

Org-12962 hydrochloride 

目录号: HY-21994

Org 12962 hydrochloride 是一种有效的、选择性的 5-HT2C 受体激动剂,对 5-HT2C,5-HT2A,5-HT2BpEC50 分别为 7.01、6.38 和 6.28。Org 12962 hydrochloride 在焦虑大鼠的模型中显示出缓解作用。

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Org-12962 hydrochloride Chemical Structure

Org-12962 hydrochloride Chemical Structure

CAS No. : 210821-63-9

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Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model[2].

IC50 & Target[1][2]

5-HT2C Receptor

7.01 (pEC50)

5-HT2A Receptor

6.38 (pEC50)

5-HT2B Receptor

6.28 (pEC50)

(In Vivo)

Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats[3]
Dosage: 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration: Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result: Had a dose-related antipanic-like effect in SD-rat.





Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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