1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Org-12962 hydrochloride

Org-12962 hydrochloride 

目录号: HY-21994
产品使用指南

Org 12962 hydrochloride 是一种有效的、选择性的 5-HT2C 受体激动剂,对 5-HT2C,5-HT2A,5-HT2BpEC50 分别为 7.01、6.38 和 6.28。Org 12962 hydrochloride 在焦虑大鼠的模型中显示出缓解作用。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

Org-12962 hydrochloride Chemical Structure

Org-12962 hydrochloride Chemical Structure

CAS No. : 210821-63-9

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Org-12962 hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Org-12962 hydrochloride:

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Org 12962 hydrochloride is a potent, selective and efficacious 5-HT2C receptor agonist and exhibits pEC50 values of 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2A, respectively. Org 12962 hydrochloride is effective in panic-like anxiety animal model[2].

IC50 & Target[1][2]

5-HT2C Receptor

7.01 (pEC50)

5-HT2A Receptor

6.38 (pEC50)

5-HT2B Receptor

6.28 (pEC50)

In Vivo

Org 12962 (intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg) displays antiaversive effects in a rat model of panic-like anxiety, it increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). The dose of 0.3 mg/kg ip is not significantly active, that the dose of 1 mg/kg is marginally active and that 3.2 mg/kg ip induced highly significant antiaversive effects[3].

Animal Model: Male Wistar rats[3]
Dosage: 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Administration: Intraperitoneal injection; 0.3 mg/kg, 1 mg/kg, and 3.2 mg/kg
Result: Had a dose-related antipanic-like effect in SD-rat.
Molecular Weight

302.12

Formula

C₁₀H₁₂Cl₂F₃N₃

CAS No.

210821-63-9

SMILES

FC(C1=C(Cl)N=C(N2CCNCC2)C=C1)(F)F.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Org-12962Org12962Org 129625-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorpanicantiaversivebrainbarrierpermeabilityBBBInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Org-12962 hydrochloride
目录号:
HY-21994
需求量: