2. Protein Tyrosine Kinase/RTK
  3. Syk
  4. OXSI-2

OXSI-2 是一种有效的、可渗透细胞的 Syk 抑制剂，EC50 为 313 nM，IC50 为 14 nM。

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OXSI-2 Chemical Structure

OXSI-2 Chemical Structure

CAS No. : 622387-85-3

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规格 价格 是否有货 数量
500 μg ￥670
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Customer Review

OXSI-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OXSI-2 is a bioavailable, cell-permeable Syk inhibitor with an EC50 of 313 nM and an IC50 of 14 nM[1][2].

体外研究
(In Vitro)

OXSI-2 (2 μM) completely inhibits Convulxin-induced platelet aggregation and shape change. OXSI-2 (2 μM) also completely blocks GPVI-mediated dense granule release. OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM[1].
Adaptor protein LAT is a known substrate of Syk Kinase. OXSI-2 completely inhibits LAT Y191 phosphorylation. OXSI-2 inhibits Syk mediated events in platelets[1].
OXSI-2 (2 μM) inhibits inflammasome assembly, caspase-1 activation, IL-1β processing and release, mitochondrial ROS generation, and pyroptotic cell death[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OXSI-2 相关抗体:

Western Blot Analysis[1]

Cell Line: Aspirin-treated, washed human platelets
Concentration: 2 μM
Incubation Time:
Result: Completely inhibited Syk-mediated LAT Y191 phosphorylation.
分子量

353.40

Formula

C18H15N3O3S
CAS 号
性状

固体

颜色

Light yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 10 mg/mL (28.30 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8297 mL 14.1483 mL 28.2965 mL
5 mM 0.5659 mL 2.8297 mL 5.6593 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

OXSI-2 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8297 mL 14.1483 mL 28.2965 mL 70.7414 mL
5 mM 0.5659 mL 2.8297 mL 5.6593 mL 14.1483 mL
10 mM 0.2830 mL 1.4148 mL 2.8297 mL 7.0741 mL
15 mM 0.1886 mL 0.9432 mL 1.8864 mL 4.7161 mL
20 mM 0.1415 mL 0.7074 mL 1.4148 mL 3.5371 mL
25 mM 0.1132 mL 0.5659 mL 1.1319 mL 2.8297 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OXSI-2622387-85-3OXSI2OXSI 2SykSpleen tyrosine kinaseInflammasomePyroptosisInflammationPotassiumTyrosinekinaseSrcGPVIsignalingPARPiceatannolInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-112386
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