1. Apoptosis
  2. TNF Receptor
  3. Ozoralizumab

Ozoralizumab  (Synonyms: ATN-103)

目录号: HY-P99796 纯度: 99.80%
COA

Ozoralizumab (ATN-103) 是一种抗 TNFα 人源化抗体。Ozoralizumab 是一种人源化三价纳米抗体化合物,由两个抗人 TNFα 纳米抗体和一个抗人血清白蛋白 (HSA) 纳米抗体组成。Ozoralizumab 可用于关节炎的研究。

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Ozoralizumab Chemical Structure

Ozoralizumab Chemical Structure

CAS No. : 1167985-17-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis[1].

体外研究
(In Vitro)

Ozoralizumab (ATN-103; 0-1000 pM; 48 h) 在 L929 细胞细胞毒性试验中具有高 TNFα 中和效力,对人 TNFα 和猴 TNFα 的 KD 值分别为 20.2 pM 和 16.1 pM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ozoralizumab (ATN-103; 1 mg/kg; s.c.; Tg197 人 TNF 转基因小鼠) 抑制关节炎并降低关节炎评分[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg197 human TNF transgenic mice[1]
Dosage: 1 mg/kg
Administration: Subcutaneous injection
Result: Reduced the mean histopathologic score in the Tg197 mice.
Had ability to neutralize TNFα activity.
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Ozoralizumab 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Ozoralizumab
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HY-P99796
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