2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Palvanil

Palvanil 是一种 Capsaicin (HY-10448) 类似物，对 TRPV1 受体表现出较强的脱敏能力，其具有抗疼痛和抗炎作用。

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Palvanil Chemical Structure

Palvanil Chemical Structure

CAS No. : 69693-13-6

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规格 价格 是否有货 数量
1 mg ￥2208
1 周
5 mg   询价  
10 mg   询价  

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Palvanil 相关抗体

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects[1][2].

体外研究
(In Vitro)

Palvanil (0.1-1000 nM; 0-300 min) leads to calcium increasment in HEK-293 intracellular[1].
Palvanil (1-10 nM; 5 min) treatment desensitizes TRPV1 to the effect of Capsaicin significantly[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Palvanil 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK-293 cells
Concentration: 0.1, 0.5, 1, 5, 10, 50, 100 and 1000 nM
Incubation Time: 0-300 min
Result: Produced a dose-dependent increase in intracellular calcium with a EC50 of 0.65 nM.

Cell Viability Assay[1]

Cell Line: HEK-293-TPRV1 cells
Concentration: 1-10 nM
Incubation Time: 5 min
Result: Desensitized TRPV1 to the effect of Capsaicin significantly (IC50=0.81 nM).
体内研究
(In Vivo)

Palvanil (subcutaneous injection; 1 or 10 mg/kg; once) treatment shows hypothermic effect[2].
Palvanil (intraperitoneal injection; 100 μL (15 nM) per mouse; once) treatment reduces Capsaicin-induced bronchoconstriction[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment shows antinociceptive effects on Formalin-induced nocifensive behavior[2].
Palvanil (intravenous injection; 0.5, 0.75, and 1 mg/kg; once) treatment inhibits Carrageenan-induced inflammation[2].
Palvanil (intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days) reduces mechanical allodynia and thermal hyperalgesia in spared nerve injury (SNI) mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice[2]
Dosage: 1 or 10 mg/kg
Administration: Subcutaneous injection; 1 or 10 mg/kg; once
Result: Led to a slight and short lasting hypothermic effect, produced late hyperthermia.
Animal Model: Female BALB/C mice[2]
Dosage: 100 μL (15 nM) per mouse
Administration: Intraperitoneal injection; 100 μL (15 nM) per mouse; once
Result: Induced a significantly lower bronchoconstriction (from 0.47 to 0.605 cm H2O/L/s).
Animal Model: Male CD-1 mice received formalin[2]
Dosage: 0.5, 0.75, and 1 mg/kg
Administration: Intravenous injection; 0.5, 0.75, and 1 mg/kg; once
Result: Reduced the second phase of Formalin-induced nociceptive behaviour in a dose-dependent manner.
Animal Model: Male C57BL/6J mice with acute inflammation induced by Carrageenan[2]
Dosage: 2.5 mg/kg
Administration: Intravenous injection; 2.5 mg/kg; once
Result: Reduced the volume of the oedema in the ipsilateral hind paw (64%).
Animal Model: Male CD-1 mice[2]
Dosage: 0.5 and 1 mg/kg
Administration: Intravenous injection; 0.5 and 1 mg/kg; once daily; 7 days
Result: Reduced mechanical allodynia and thermal hyperalgesia at 3 and 7 days after nerve injury in a dose-dependent manner.
分子量

391.59

Formula

C24H41NO3
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Palvanil 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palvanil69693-13-6TRP ChannelTransient receptor potential channelsanti-nociceptiveanti-inflammationHEK-293Inhibitorinhibitorinhibit

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目录号：
HY-137988
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