1. Neuronal Signaling Protein Tyrosine Kinase/RTK Apoptosis
  2. Trk Receptor Apoptosis
  3. Pan-Trk-IN-3

Pan-Trk-IN-3 (Compound 11g) 是一种有效的广谱 Trk 及其耐药突变体抑制剂。对 TrkATrkBTrkCTrkAG595RTrkAG667CTrkAG667STrkAF589LTrkCG623RIC50 分别为 2、3、2、21、26、5、7 和 6 nM。Pan-Trk-IN-3 表现出极好的抗肿瘤活性,诱导细胞凋亡 (apoptosis)。

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Pan-Trk-IN-3 Chemical Structure

Pan-Trk-IN-3 Chemical Structure

CAS No. : 2763637-66-5

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查看 Trk Receptor 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pan-Trk-IN-3 (Compound 11g) is a potent inhibitor of pan-Trk and their drug-resistant mutants with IC50 values of 2, 3, 2, 21, 26, 5, 7 and 6 nM against TrkA, TrkB, TrkC, TrkAG595R, TrkAG667C, TrkAG667S, TrkAF589L and TrkCG623R, respectively. Pan-Trk-IN-3 displays excellent antitumor activity and induces apoptosis[1].

IC50 & Target

TrkA

2 nM (IC50)

TrkC

2 nM (IC50)

TrkB

3 nM (IC50)

TrkAG667S

5 nM (IC50)

TrkCG623R

6 nM (IC50)

TrkAF589L

7 nM (IC50)

TrkAG595R

21 nM (IC50)

TrkAG667C

26 nM (IC50)

分子量

575.06

Formula

C29H31ClN8O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Pan-Trk-IN-3
目录号:
HY-144069
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