2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Panitumumab

Panitumumab  (Synonyms: ABX-EGF)

目录号: HY-P99041 纯度: 98.80%
COA

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Panitumumab (ABX-EGF) 是一种全人源 IgG2 抗 EGFR 单克隆抗体，具有抗肿瘤活性。Panitumumab 抑制肿瘤细胞增殖、存活和血管生成。Panitumumab 可用于癌症研究，例如结肠癌。

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Panitumumab Chemical Structure

Panitumumab Chemical Structure

CAS No. : 339177-26-3

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Panitumumab 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer[1][2][4].

体外研究
(In Vitro)

Panitumumab (2 nM-2 μM，3 小时) 抑制表达 EGFR 的 NCI-H1975 细胞、NCI-H1650 细胞和 CHO 细胞中的配体依赖性自磷酸化[3]。
Panitumumab (0 -200 μg/mL，48 h) 抑制DLD-1细胞增殖[4]。
Panitumumab (80 μg/mL，24 h) 增加beclin-1 (一种标志物自噬) 在 Caco-2 细胞和 DLD-1 细胞中的水平[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Panitumumab 相关抗体:

Western Blot Analysis[3]

Cell Line: EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells
Concentration: 2, 20, 200, 2000 nM
Incubation Time: 3 h
Result: Inhibited ligand-induced autophosphorylation of EGFR.
体内研究
(In Vivo)

与对照相比，Panitumumab (25、100 或 500 μg/小鼠，ip，每周两次) 抑制 NCI-H1975 和 NCI-H1650 异种移植模型中的肿瘤生长 (P < 0.0003)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-H1975 and NCI-H1650 xenografts[3]
Dosage: 25, 100, or 500 μg/mouse
Administration: Intraperitoneal injection (i.p.), twice a week
Result: Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation.
Decreased Ki-67 and phospho- mitogen-activated protein kinase (pMAPK) staining in both xenografts.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

帕尼单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.80%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Panitumumab 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Panitumumab339177-26-3ABX-EGF帕尼单抗EGFREpidermal growth factor receptorErbB-1HER1human IgG2anti-EGFRmonoclonal antibodyanti-tumorNCI-H1975NCI-H1650CHODLD-1Caco-2Inhibitorinhibitorinhibit

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