2. Anti-infection
  3. Bacterial
  4. Panobacumab

Panobacumab  (Synonyms: KBPA101)

目录号: HY-P99214 纯度: 96.80%
COA

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Panobacumab (KBPA101) 是一种完全人 IgM/κ 单克隆抗体，由人类B淋巴细胞产生，对血清型 O11 P. aeruginosa 的 LPS O 多糖具有抗性。

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Panobacumab Chemical Structure

Panobacumab Chemical Structure

CAS No. : 885053-97-4

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Panobacumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Panobacumab (KBPA101) is a fully human IgM/κ monoclonal antibody generated by immortalizing human B lymphocytes against the LPS O polysaccharide of serotype O11 of P. aeruginosa[1].

体外研究
(In Vitro)

Panobacumab (KBPA101) strongly binds to 18 of 20 clinical O11 isolates, functional avidity of KBPA101 to O11 LPS determined by inhibition ELISA is 5.81×107 M-1± 2.8×107 M-1[1].
Panobacumab (KBPA101) (0.0001-100 ng/mL; 2 h) specifically mediates complement-dependent opsonophagocytosis of P. aeruginosa serotype O11 with an IC50 of 0.16 ng/mL[1].
Panobacumab (KBPA101) (0.1-10 ng/mL) shows direct complement-dependent killing of P. aeruginosa serotype O11 cells in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Panobacumab 相关抗体:
体内研究
(In Vivo)

Panobacumab (KBPA101) (1-4 mg/kg; i.v.; once) protects mice from systemic infection with P. aeruginosa serotype O11 in a murine burn wound model[1].
Panobacumab (KBPA101) (0.005-0.4 mg/kg; i.v.; once) protects mice from local lung infection with P. aeruginosa serotype O11 in an acute lung infection model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NMRI mice, murine burn wound model[1]
Dosage: 1, 2, or 4 mg/kg
Administration: Intravenous injection, single dose
Result: Significantly reduced mortality compared to untreated control animals administered either immediately or 4 h postchallenge.
Animal Model: BALB/c mice, acute lung infection model[1]
Dosage: 0.005 to 0.4 mg/kg
Administration: Intravenous injection, single dose
Result: Led to rapid clearance of P. aeruginosa from the lung, completely cleared systemic P. aeruginosa from the spleen, whereas live bacteria were still present in untreated mice at 48 h postchallenge, showed milder macroscopic lung pathology at 6 and 24 h after infection.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

帕巴库单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Panobacumab 相关分类

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Keywords:

Panobacumab885053-97-4KBPA101帕巴库单抗KBPA 101KBPA-101BacterialP. aeruginosaB lymphocytesLPS O polysaccharideserotype O11Inhibitorinhibitorinhibit

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