2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-32

PD-1/PD-L1-IN-32 (compound A56) 是一种有效的 PD-1/PD-L1 抑制剂 (IC50=2.4 nM)，具有抗癌活性。PD-1/PD-L1-IN-32 能显著抑制 hPD-L1 MC38 人源化小鼠模型的肿瘤生长，对小鼠无明显毒性。

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PD-1/PD-L1-IN-32 Chemical Structure

PD-1/PD-L1-IN-32 Chemical Structure

CAS No. : 2765535-21-3

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PD-1/PD-L1-IN-32 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability[1].

IC50 & Target

IC50: 2.4 nM (PD-1/PD-L1)[1]
体内研究
(In Vivo)


PD-1/PD-L1-IN-32 (compound A56) 在 SD 大鼠中的药代动力学分析[1]

Route Dose (mg/kg) AUC(0-t) (μg/L·h) AUC(0-∞) (μg/L·h) Cmax (μg/L) Tmax (h) t1/2 (h) V1 (L/kg) CL (L/h/kg) F (%)
iv 8 11487.46 13353.19 6227.50 0.08 0.99 1.09 0.60
ig 40 63579.08 65527.75 21504.90 1.75 1.72 1.80 0.62 114.09
ip 10 9729.84 10504.11 4156.54 0.88 2.43 2.94 1.21

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

517.98

Formula

C29H25ClFN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-1/PD-L1-IN-32 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-322765535-21-3PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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