2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-43

PD-1/PD-L1-IN-43 (化合物 Z13) 是一种 PD-1/PD-L1 相互作用的小分子靶向抑制剂。PD-1/PD-L1-IN-43 对 B16-F10 黑色素瘤具有较强的体内抗肿瘤作用。PD-1/PD-L1-IN-43 通过阻断 PD-1 和 PD-L1 的相互作用抑制肿瘤生长。PD-1/PD-L1-IN-43 可用于抗肿瘤研究。

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PD-1/PD-L1-IN-43 Chemical Structure

PD-1/PD-L1-IN-43 Chemical Structure

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PD-1/PD-L1-IN-43 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1/PD-L1-IN-43 (compound Z13) is a small-molecule inhibitors targeting the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-43 exhibites potent in vivo antitumor efficacy against B16-F10 melanoma. PD-1/PD-L1-IN-43 inhibits tumor growth by blocking the interaction between PD-1 and PD-L1. PD-1/PD-L1-IN-43 can be used in anti-tumor studies[1].
体外研究
(In Vitro)

PD-1/PD-L1-IN-43 (0 - 20 μM; 48 h) 可以激活免疫抑制的 Jurkat T 细胞，杀死细胞共培养系统中的 HepG2 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-1/PD-L1-IN-43 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2/Jurkat co-culture cell model
Concentration: 0 - 20 μM
Incubation Time: 48 h
Result: Reduced the survival rate of HepG2 cells to 55.16% compared to the control group.
体内研究
(In Vivo)

PD-1/PD-L1-IN-43 (20 和 40 mg/kg； 腹腔注射， 每天一次持续 2 周) 通过激活肿瘤免疫微环境有效抑制 C57BL/6J 雄性小鼠体内肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mouse model of B16-F10 melanoma
Dosage: 20 and 40 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: The tumor growth inhibition values (TGI) of the treatment groups were 42.4 % and 52.6 % at doses of 20 and 40 mg/kg.
分子量

455.51

Formula

C27H25N3O4
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-1/PD-L1-IN-43 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-43PD-1/PD-L1PD-1/Programmed death-ligand 1HepG2 cellsB16-F10 melanoma mouse modelPD-1/PD-L1 inhibitortumor immunologyInhibitorinhibitorinhibit

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产品名称：
PD-1/PD-L1-IN-43
目录号：
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