1. Apoptosis
  2. Apoptosis
  3. Peginterferon beta-1a

Peginterferon beta-1a  (Synonyms: Peginterferon β-1a)

目录号: HY-108790

Peginterferon beta-1a (Peginterferon β-1a) 是首个聚乙二醇化干扰素 beta-1a 分子。Peginterferon beta-1a 诱导癌细胞凋亡并且在裸鼠模型中显示出抗肿瘤活性。Peginterferon beta-1a 可用于癌症和多发性硬化 (RMS) 的研究。

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Peginterferon beta-1a Chemical Structure

Peginterferon beta-1a Chemical Structure

CAS No. : 1211327-92-2

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Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS)[1].

(In Vitro)

Peginterferon beta-1a (0.001-1000 ng/mL; 5 d) affects cell viability of SK-MEL-2, SK-MEL-5, MeWo and WM-266-4 tumor cells[1].
Peginterferon beta-1a (10, 100, and 1,000 ng/mL) induces cell apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SK-MEL-1, SK-MEL-2, SK-MEL-5, MeWo and WM-266-4 tumor cell lines
Concentration: 0.001-1000 ng/mL
Incubation Time: 5 d
Result: Inhibited the cell viability of SK-MEL-2, SK-MEL-5, MeWo and WM-266-4 tumor cells and showed an IC50 value of 2-3 ng/mL to WM-266-4 cells.

Western Blot Analysis[1]

Cell Line: WM-266-4 cell line
Concentration: 10, 100 and 1000 ng/mL
Incubation Time: 24 h
Result: Induced the cleavage of PARP, caspase-8, and -9, induction of TRAIL and phosphorylation of STAT1.
(In Vivo)

Peginterferon beta-1a (0.1-1.6 mg/kg; s.c. QW/BIW/TIW for 3-4 weeks) inhibits SK-MEL-1, A-375 melanoma and WM-266-4 melanoma cancer growth in xenografts nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with human SK-MEL-1 and A-375 melanoma xenografts[1]
Dosage: 0.1-1.6 mg/kg
Administration: Subcutaneous injection; once/twice a week; for 3/4 weeks
Result: Significantly inhibited SK-MEL-1 tumor growth at 0.4 mg/kg (QW; 3 w) and inhibited A-375 melanoma tumors at 1.6 mg/kg (BIW; 4 w).
Animal Model: Nude mice with human WM-266-4 melanoma xenografts[1]
Dosage: 0.4-1.6 mg/kg
Administration: Subcutaneous injection; 0.4-1.6 mg/kg; once/twice/three times a week for 4 w
Result: The QW dose of 1.6 mg/kg and all doses given BIW and TIW induced tumor regression, with a 1.6 mg/kg QW dose induced significant tumor inhibition relative to 0.8 mg/kg QW.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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