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  3. Pemetrexed disodium-13C5

Pemetrexed disodium-13C5  (Synonyms: LY231514 disodium-13C5)

目录号: HY-W769288
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Pemetrexed disodium-13C5 (LY231514 disodium-13C5) 是 13C 标记的 Pemetrexed disodium (HY-10820A)。Pemetrexed disodium (LY231514 disodium) 是一种叶酸拮抗剂 (antifolate)。Pemetrexed disodium 抑制胸苷酸合成酶 (TS),二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT) 的 Ki 分别为 1.3 nM,7.2 nM 和 65 nM。

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Pemetrexed disodium-<sup>13</sup>C<sub>5</sub> Chemical Structure

Pemetrexed disodium-13C5 Chemical Structure

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  • 生物活性

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生物活性

Pemetrexed disodium-13C5 (LY231514 disodium-13C5) is the 13C-labeled Pemetrexed disodium (HY-10820A). Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

476.34

同用名

LY231514 disodium-13C5

Formula

C1513C5H19N5Na2O6

非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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参考文献
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