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  2. Pentetreotide

Pentetreotide 

目录号: HY-P2022
产品使用指南

Pentetreotide 是 Octreotide 的 DTPA 共轭物。Pentetreotide 是一种铟标记的生长抑素类似物,可用于核医学成像。Pentetreotide 与生长抑素受体闪烁显影可有效观察神经内分泌肿瘤及其转移。

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Pentetreotide Chemical Structure

Pentetreotide Chemical Structure

CAS No. : 138661-02-6

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Description

Pentetreotide is a diethylenetriaminopentaacetic (DTPA) conjugate of Octreotide. Pentetreotide is an indium-labelled somatostatin analog and can be uesd to nuclear medicine imaging. Somatostatin receptor scintigraphy with Pentetreotide is effective in visualizing neuroendocrine tumors, and its metastasis[1][2].

In Vitro

Neuroendocrine tumors have an increased number of somatostatin receptors, as compared to normal tissues. At present time, there are five known subtypes. Somatostatin receptor scintigraphy with 111In-Pentetreotide binds to two of these subtypes and is effective in visualizing neuroendocrine tumors, and its metastasis with an overall diagnostic sensitivity of 70% to 90%. It is considerably more sensitive than conventional anatomic imaging. Its usage in neuroendocrine tumors not only includes assessment of disease extent, but also in identified primary lesion, assesses treatment response, and selection for radionuclide therapy[1].

Molecular Weight

1394.57

Formula

C₆₃H₈₇N₁₃O₁₉S₂

CAS No.

138661-02-6

Sequence

{Gly}{Phe}{Cys}{Phe}{Trp}{Lys}{Thr}{Cys}{Thr} (Disulfide bridge: Cys3-Cys8)

Sequence Shortening

G{D-Phe}CF{D-Trp}KTCT (Disulfide bridge: Cys3-Cys8)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PentetreotideOthersDTPAindium-labelledtumurtracerscintigraphysomatostatinmetastasisSPECTCTInhibitorinhibitorinhibit

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产品名称:
Pentetreotide
目录号:
HY-P2022
需求量: