1. Anti-infection Metabolic Enzyme/Protease Autophagy
  2. HIV Protease Autophagy
  3. Pepstatin acetate

Pepstatin acetate  (Synonyms: Pepstatin A acetate)

目录号: HY-P0018C
产品使用指南

Pepstatin (Pepstatin A) acetate 是由放线菌类产生的一种特异性的、具有口服活性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin、hemoglobin-proctase、casein-pepsin、casein-proctase、casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM、6.2 nM、150 nM、290 nM、520 nM 和 260 nM;同时可抑制 HIV protease 的活性。

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Custom Peptide Synthesis

Pepstatin acetate Chemical Structure

Pepstatin acetate Chemical Structure

CAS No. : 28575-34-0

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Pepstatin acetate 的其他形式现货产品:

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Other Forms of Pepstatin acetate:

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Top Publications Citing Use of Products

    Pepstatin acetate purchased from MCE. Usage Cited in: Pharmaceuticals. 2022, 15(12), 1509

    TSN (10 μM), Baf (0.5 μM), and E64D (25 μM) plus pepstatin A (50 μM; E + P ) treatment significantly inhibits the degradation ability of lysosomes (in HepG2 cells and L02 cells; medium for 6 h).
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Pepstatin (Pepstatin A) acetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin acetate also inhibits HIV protease[1][2].

    IC50 & Target

    IC50: 4.5 nM (Hemoglobin-pepsin), 6.2 nM (Hemoglobin-proctase), 150 nM (Casein-pepsin), 260 nM (Hemoglobin-acid protease), 290 nM (Casein-proctase), 520 nM (Casein-acid protease)[1]

    体外研究
    (In Vitro)

    Pepstatin (Pepstatin A) (7 μM; 48 h) affects the intracellular processing of HIV-specific gag protein[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    体内研究
    (In Vivo)

    Pepstatin (Pepstatin A) has a very low toxicity, with LD50s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route[1].
    Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Pylorus ligated male Wistar rats[1]
    Dosage: 0.5, 1, 10 and 50 mg/kg
    Administration: Oral administration, 15 minutes after pyloric ligation
    Result: Effectively prevented stomach ulceration.
    分子量

    745.94

    Formula

    C36H67N5O11

    CAS 号
    Sequence Shortening

    {Ac}-VV-{Sta}-A-{Sta}

    中文名称

    抑肽素醋酸盐

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Pepstatin acetate
    目录号:
    HY-P0018C
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