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  2. Peptide C105Y TFA

Peptide C105Y TFA 

目录号: HY-P1781A
产品使用指南

Peptide C105Y TFA,基于 α1-抗胰蛋白酶 359-374 残基氨基酸序列合成的细胞穿透性肽,能增强 DNA 纳米粒的基因表达。

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Peptide C105Y TFA Chemical Structure

Peptide C105Y TFA Chemical Structure

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Description

Peptide C105Y TFA, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles[1].

In Vitro

When human hepatoma cells (HuH7) were incubated with fluorescently labeled C105Y for as little as 3 min, C105Y displays nuclear and cytoplasmic staining with enrichment of fluorescent signal in the nucleus and nucleolus. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion, whereas membrane translocation and nuclear localization are energy-independent. When tested the involvement of known endocytosis pathways in uptake and trafficking of this peptide, C105Y peptide is internalized by a clathrin- and caveolin-independent pathway, although lipid raft-mediated endocytosis may play a role in peptide intracellular trafficking[1].

Molecular Weight

2108.42

Formula

C₉₉H₁₄₉F₃N₂₀O₂₅S

Sequence Shortening

CSIPPEVKFNKPFVYLI

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Peptide C105YOtherscell-penetratingα1-antitrypsingeneexpressionnanoparticlesDNAInhibitorinhibitorinhibit

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产品名称:
Peptide C105Y TFA
目录号:
HY-P1781A
需求量: