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  3. Perillic acid

Perillic acid  (Synonyms: 紫苏酸)

目录号: HY-113471
产品使用指南

Perillic acid 是 Perillyl alcohol (HY-N7000) 的代谢物。Perillic acid 诱导肺癌细胞周期阻滞和凋亡 (apoptosis)。Perillic acid 具有抗 HSV-1 和免疫调节活性。

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Perillic acid Chemical Structure

Perillic acid Chemical Structure

CAS No. : 7694-45-3

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Other Forms of Perillic acid:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Perillic acid is the metabolite of Perillyl alcohol (HY-N7000). Perillic acid induces lung cancer cell cycle arrest and apoptosis. Perillic acid shows anti-HSV-1 and immunomodulatory activities[1][2][3].

IC50 & Target[2]

HSV-1

 

体外研究
(In Vitro)

Perillic acid (1-5 mM; 24 h) 以剂量依赖的方式降低 A549 细胞的存活率[1]
Perillic acid (1 mM; 24 h) 诱导 A549 细胞 S 期阻滞,诱导 H520 细胞 G2/M 期阻滞[1]
Perillic acid (2 mM; 24 h) 诱导 A549 和 H520 细胞凋亡[1]
Perillic acid (0-50 μM; 24 h) 显示出主要针对 17syn+ HSV-1 的抗病毒活性 (EC50 KOS: 2.84 μM; 17syn+: 1.08 μM)[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: A549 cells
Concentration: 1, 2, 3, 4 and 5 mM
Incubation Time: 24 h
Result: Resulted in decreased survival in a dose-dependent manner with an IC50 of 3.6 mM.

Cell Cycle Analysis[1]

Cell Line: A549 and H520 cells
Concentration: 1 mM
Incubation Time: 24 h
Result: Induced S-phase arrest in A549 cells and induced G2/M arrest in H520 cells.

Apoptosis Analysis[1]

Cell Line: A549 and H520 cells
Concentration: 2 mM
Incubation Time: 24 h
Result: Increased apoptosis to 27% in A549 and to 18% in H520 cells compared to control (12%).

Western Blot Analysis[1]

Cell Line: H520 cells
Concentration: 0.5 mM
Incubation Time: 24 h
Result: Increased Bax expression and decreased procaspase-3 levels.
体内研究
(In Vivo)

Perillic acid (50 μM/kg; i.p.; daily for 5 days) 显示小鼠免疫调节活性[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice[3]
Dosage: 50 μM/kg
Administration: Intraperitoneal injection, daily for 5 days
Result: Increased the total white blood cells (WBC) count. Increased the total antibody production, antibody producing cells in spleen, bone marrow cellularity and α-esterase positive cells significantly compared to the normal animals.
分子量

166.22

Formula

C10H14O2

CAS 号
中文名称

紫苏酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Perillic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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