(S)-(-)-Perillic acid  (Synonyms: (S)-(-)-紫苏酸)

(S)-(-)-Perillic acid is a terpenoid plant extract with antimicrobial and anticancer activities. (S)-(-)-Perillic acid induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, p21 and caspase-3 proteins. (S)-(-)-Perillic acid can be used for cancer and infection research^[1][2][3].

(S)-(-)-Perillic acid (1.0-3.5 mM；24，48 和 72 小时) 时间和剂量依赖性地抑制动脉平滑肌细胞 (SMCs) 的生长^[1]。
(S)-(-)-Perillic acid (1.0-3.5 mM；20 小时) 剂量依赖性地抑制大鼠动脉平滑肌细胞 (SMC) 胸腺嘧啶核内结合^[1]。
(S)-(-)-Perillic acid (2.5 mM；24 小时) 阻滞 G0/G1 期细胞周期进程，诱导动脉平滑肌细胞凋亡^[1]。
(S)-(-)-Perillic acid (1.0-3.5 mM；20小时) 剂量依赖性抑制 [³H]FOH 和[³H]GGOH 掺入特定低分子量蛋白^[1]。
(S)-(-)-Perillic acid (0.5 mM；24小时) 提高 H520 细胞中 Bax，Bcl2，p21 和 caspase-3 蛋白水平^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

166.22

C₁₀H₁₄O₂

23635-14-5

(S)-(-)-紫苏酸

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ferri N, et al. Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. Biochem Pharmacol. 2001 Dec 15;62(12):1637-45.  [Content Brief]

  [2]. Yeruva L, et al. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer Lett. 2007 Nov 18;257(2):216-26.  [Content Brief]

  [3]. Khandelia H, et al. Interaction of salicylate and a terpenoid plant extract with model membranes: reconciling experiments and simulations. Biophys J. 2010 Dec 15;99(12):3887-94.  [Content Brief]