2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Photosensitizer Apoptosis Reactive Oxygen Species (ROS)
  4. Photosensitizer-7

Photosensitizer-7 是一种靶向内质网 (ER) 的光敏剂 (PS) (λab = 610 nm, λem = 622 nm)。Photosensitizer-7 在光照条件下对 HeLa 细胞的 IC50 为 4.006 μM，对 MCF-7 细胞的 IC50 为 3.28 μM。Photosensitizer-7 表现出剂量依赖性的细胞摄取，并主要与内质网共定位。Photosensitizer-7 在细胞中通过光照诱导剂量依赖性的细胞内 ROS 生成，降低线粒体膜电位，并增加细胞凋亡 (apoptosis)。Photosensitizer-7 显著抑制 MCF-7 荷瘤小鼠的肿瘤生长。Photosensitizer-7 可用于光动力抗癌应用的研究。

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Photosensitizer-7

Photosensitizer-7 Chemical Structure

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Photosensitizer-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Photosensitizer-7 is a endoplasmic reticulum (ER)-targeted photosensitizer (PS) (λab = 610 nm, λem = 622 nm). Photosensitizer-7shows an IC50 of 4.006 μM in HeLa cells and 3.28 μM in MCF-7 cells under light irradiation. Photosensitizer-7 exhibits dose-dependent cellular uptake and predominant colocalization with ER. Photosensitizer-7 induces dose-dependent intracellular ROS generation, reduces mitochondrial membrane potential, and increases apoptosis upon light irradiation in cells. Photosensitizer-7 significantly inhibits tumor growth in MCF-7 tumor-bearing mice. Photosensitizer-7 can be used for the study of photodynamic anticancer applications[1].

体外研究
(In Vitro)

Photosensitizer-7 (Compound 4j) 的吸收最大值在 610 nm，莫尔消光系数为 53,000 M-1cm-1，荧光发射最大值在 622 nm，荧光量子产率为 0.38，单线态氧量子产率为 0.44[1]。
Photosensitizer-7 (24 h) 在光照条件下对 HeLa 细胞的 IC50 为 4.006 μM，对 MCF-7 细胞的 IC50 为 3.28 μM，而在黑暗条件下，其 IC50 在 HeLa 细胞中为 19.93 μM，在 MCF-7 细胞中为 135.9 μM[1]。
Photosensitizer-7 (2-8 μM, 24 h) 在黑暗条件下对 MCF-7 细胞的细胞内 ROS 产生影响可忽略不计，而在光照条件下，其触发显著的剂量依赖性 ROS 水平增加[1]。
Photosensitizer-7 (2-8 μM, 24 h) 在光激发下引起 MCF-7 细胞线粒体膜电位 (ΔΨm) 的剂量依赖性降低，并增加细胞凋亡率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Photosensitizer-7 相关抗体:

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2, 4, 8 μM
Incubation Time: 24 h
Result: Increased the apoptosis rate of MCF-7 cells under light excitation.
体内研究
(In Vivo)

Photosensitizer-7 (Compound 4j) (5-40 mg/kg，腹腔给药，每 3 天一次，持续 21 天) 在雄性 ICR 小鼠中未显示异常行为变化、显著的体重差异或主要器官 (心、肝、脾、肺、肾) 的病理变化[1]。
Photosensitizer-7 (20-40 mg/kg，瘤内注射，单次给药) 在 MCF-7 荷瘤雌性 BALB/c 裸鼠中显著抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCF-7 cells (1 × 107 cells/mouse in appropriate volume of normal saline) were subcutaneously implanted into the right flanks of 5-week-old female BALB/c nude mice[1]
Dosage: 20 mg/kg, 40 mg/kg
Administration: Intratumoral injection followed by 30 J/cm2 light irradiation 1 h later at once
Result: Inhibited tumor growth.
Showed no significant changes in body weight.
Reduced tumor cell nuclear density and caused significant deformation of tumor cell nuclei in MCF-7 tumor tissues.
分子量

700.57

Formula

C43H37BF4N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Photosensitizer-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Photosensitizer-7Photosensitizer7Photosensitizer 7PhotosensitizerApoptosisReactive Oxygen Species (ROS)MCF-7 cellsphotosensitizerHeLa cellsendoplasmic reticulumapoptosisInhibitorinhibitorinhibit

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