2. JAK/STAT Signaling
  3. Pim
  4. Pim-1/2 kinase inhibitor 2

Pim-1/2 kinase inhibitor 2 (compound 5b) 是一种竞争性 PIM-1 和 PIM-2 激酶抑制剂，IC50 分别为 1.31 μM 和 0.67 μM。Pim-1/2 kinase inhibitor 2 对正常人肺成纤维细胞 Wi-38 细胞系显示出低细胞毒性，对骨髓性白血病 (NFS-60)、肝脏 (HepG-2)、前列腺 (PC) 具有有效的体外抗癌活性 -3) 和结肠 (Caco-2) 癌细胞系。

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Pim-1/2 kinase inhibitor 2 Chemical Structure

Pim-1/2 kinase inhibitor 2 Chemical Structure

CAS No. : 2918764-16-4

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Pim-1/2 kinase inhibitor 2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines[1].

IC50 & Target[1]

PIM1

1.31 μM (IC50)

PIM2

0.67 μM (IC50)

分子量

458.90

Formula

C25H19ClN4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pim-1/2 kinase inhibitor 2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pim-1/2 kinase inhibitor 22918764-16-4PimPim kinasesPIM-1PIM-2anticancer activityInhibitorinhibitorinhibit

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