Pipamperone dihydrochloride  (Synonyms: Floropipamide dihydrochloride; McN-JR 3345 dihydrochloride; R 3345 dihydrochloride)

Pipamperone dihydrochloride (Floropipamide dihydrochloride) is a butyrophenone derivative and high-affinity antagonist of 5-HT_2A receptor (pK_i=8.2) and D₄ receptor (pK_i=8.0). Pipamperone dihydrochloride is also a low-affinity antagonist of D₂ receptor (pK_i=6.7). Pipamperone dihydrochloride affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone dihydrochloride is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease^[1][2][3][4].

Pipamperone (0.01 nM-10 μM; 20 min) dihydrochloride 完全抑制 5-HT (HY-B1473A) 诱导的稳定表达大鼠 5-HT_2A 或 5-HT_2C 受体 NIH 3T3 细胞中的 Inositol phosphate 形成^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

448.40

C₂₁H₃₂Cl₂FN₃O₂

2448-68-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Erik Buntinx, MD, et al. Selective Serotonergic Properties of Low-Dose Pipamperone May Enhance Antidepressant Effect: Preclinical Evidence.

  [2]. Oekelen DV, et al. Different regulation of rat 5-HT(2A) and rat 5-HT(2C) receptors in NIH 3T3 cells upon exposure to 5-HT and pipamperone. Eur J Pharmacol. 2001 Aug 3;425(1):21-32.  [Content Brief]

  [3]. Petrosino B, et al. The treatment of autism with pipamperone: a case report. European Psychiatry, 2016, 33(S1): S549-S549.

  [4]. Kamp D, et al. Hypothermia in a patient with Alzheimer's disease receiving a combination therapy with risperidone and pipamperone. Ther Adv Psychopharmacol. 2016 Feb;6(1):55-7.  [Content Brief]