2. Apoptosis
  3. TNF Receptor
  4. Placulumab

Placulumab  (Synonyms: ART621; CEP-37247; PN0621)

目录号: HY-P99775

摩尔计算器

Placulumab (ART621) 是一种抗 TNF α 单克隆抗体。Placulumab 具有抗炎活性，在关节炎等炎性疾病中有潜在应用。

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Placulumab Chemical Structure

Placulumab Chemical Structure

CAS No. : 945781-29-3

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规格 是否有货
1 mg   询价  
5 mg   询价  
10 mg   询价  

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Customer Review

Placulumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis[1].

体外研究
(In Vitro)

Placulumab (0.01-1000 µg/mL) 对 NS0 细胞和外周血单个核细胞 (PBMC) 具有细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Placulumab 相关抗体:
体内研究
(In Vivo)

Placulumab (0.3、1、3 和 10 mg/kg；腹腔注射；每周两次持续 8 周) 在 Tg197 转基因小鼠模型中具有有效的抗关节炎特性[1]。
Placulumab 在食蟹猴中的药代动力学 (PK) 参数[1]

Route Dose (mg/kg) Exposure AUC0-336 h (ng.h/mL) Maximum concentration Cmax (ng/mL) Time of maximum concentration tmax (h) Elimination half-life t1/2 (h) Clearance CL (mL/hr/kg)
Intravenous injection (Males) 50 46000000 1320000 0.167 104 0.985
Intravenous injection (Females) 50 43300000 1020000 0.211 97.4 1.06
Route Dose (mg/kg) Exposure AUC0-336 h (ng.h/mL) Dose normalize exposure AUC0-336 h (norm) Maximum concentration Cmax (ng/mL) Time of maximum concentration tmax (h) Elimination half-life t1/2 (h)
Subcutaneous injection (Males) 0.5 676000 1350000 3190 50.0 120
Subcutaneous injection (Females) 0.5 445000 890000 2880 48.0 108
Subcutaneous injection (Males) 5 3940000 788000 22700 40.0 117
Subcutaneous injection (Females) 5 3840000 767000 23800 12.0 109
Subcutaneous injection (Males) 50 41600000 832000 272000 40.0 122
Subcutaneous injection (Females) 50 32300000 646000 212000 32.0 107

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Placulumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Placulumab945781-29-3ART621 CEP-37247 PN0621ART 621ART-621CEP37247CEP 37247CEP-37247PN0621PN 0621PN-0621TNF ReceptorTumor Necrosis Factor ReceptorTNFRNS0PBMCMouseInhibitorinhibitorinhibit

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