Polyadenylic acid potassium  (Synonyms: Poly(A))

Polyadenylic acid potassium, also known as Poly(A), is enzymatically added to messenger RNA (mRNA) in eukaryotic cells to stabilize mRNAs. Poly(A) is used to evaluate binding on cationic liposomes doped with non-ionic nucleolipids. Poly(A) is used in small molecule mRNA targeted drug development to evaluate the binding of potential therapeutic agents such as the Isoquinoline group of alkaloids. Small molecules that could bind to this poly(A) tail could influence and possibly inhibit mRNA function and subsequent protein production in the cell leading to the development of new type of therapeutic agents.

26763-19-9

固体

White to off-white

聚腺苷酸钾盐

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Methods of biochemical analysis[M]. John Wiley & Sons, 2009.

  [2]. Cuomo F, Ceglie A, Colafemmina G, Germani R, Savelli G, Lopez F. Polyadenylic acid binding on cationic liposomes doped with the non-ionic nucleolipid Lauroyl Uridine. Colloids Surf B Biointerfaces. 2011 Feb 1;82(2):277-82.  [Content Brief]

  [3]. Giri P, Kumar GS. Molecular aspects of small molecules-poly(A) interaction: an approach to RNA based drug design. Curr Med Chem. 2009;16(8):965-87.  [Content Brief]