2. PROTAC
  3. Ligands for E3 Ligase
  4. N-Methylated pomalidomide

N-Methylated pomalidomide  (Synonyms: Pomalidomide-methyl)

目录号: HY-W586822 纯度: 97.86%
COA 产品使用指南 技术支持

N-methylated pomalidomide (Pomalidomide-methyl) 是 Pomalidomide (HY-10984) 的衍生物，是一种 cereblon (CRBN) 配体。N-methylated pomalidomide 无法募集 CRBN，可用作 Pomalidomide 的阴性对照。N-methylated pomalidomide 可用于合成 PROTAC。

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N-Methylated pomalidomide Chemical Structure

N-Methylated pomalidomide Chemical Structure

CAS No. : 1352827-50-9

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100 mg ￥450
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250 mg ￥828
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1 g ￥2119
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N-Methylated pomalidomide 相关抗体

Top Publications Citing Use of Products

查看 Ligands for E3 Ligase 亚型特异性产品:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-methylated pomalidomide (Pomalidomide-methyl), a derivative of Pomalidomide (HY-10984), is a cereblon (CRBN) ligand. N-methylated pomalidomide is unable to recruit CRBN that can be used as a negative control for Pomalidomide. N-methylated pomalidomide can be used to synthesize PROTAC[1].

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

PROTAC 包含两个不同的配体，通过一个接头连接；一个是 E3 泛素连接酶的配体，另一个是靶蛋白的配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N-Methylated pomalidomide 相关抗体:
分子量

287.27

同用名

Pomalidomide-methyl

Formula

C14H13N3O4
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 97.86%

COA (292 KB) HNMR (133 KB) RP-HPLC (282 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献

N-Methylated pomalidomide 相关分类

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Keywords:

N-Methylated pomalidomide1352827-50-9Pomalidomide-methylLigands for E3 LigaseE3 ligase-recruiting MoietyCRBN ligandnegative controlPROTACInhibitorinhibitorinhibit

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