1. Neuronal Signaling
  2. Tau Protein
  3. Posdinemab

Posdinemab  (Synonyms: JNJ-63733657)

目录号: HY-P9995 纯度: ≥99.0%
COA 技术支持

Posdinemab (JNJ-63733657) 是一种选择性靶向磷酸化 tau (pT217) 的人源化 IgG1/κ 单克隆抗体。Posdinemab 特异性结合富含脯氨酸结构域的 pT217+tau 表位,阻断 tau 蛋白聚集及种子传播,促进细胞外 tau 物种的清除。Posdinemab 减少脑脊液中游离和总 p217+tau 水平,从而抑制 tau 蛋白的病理传播和神经纤维缠结形成。Posdinemab 可用于进行性核上性麻痹综合征和阿尔茨海默症 (AD) 研究,尤其针对前驱期或轻度 AD 疾病。

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CAS No. : 2517973-04-3

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217). Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease[1][2][3].

同型

Human IgG1 kappa

推荐同型对照抗体
种属

Humanized

IC50 & Target

MAPT

体外研究
(In Vitro)

人工脑脊液及小鼠脑匀浆实验[2]
Posdinemab (100 nM;免疫沉淀孵育过夜+酶解 20 h) 特异性结合磷酸化 tau (p217+tau),通过免疫沉淀富集目标肽段,检测到含 pT217 位点的双磷酸化 tau 肽 SRTPSLPTPPTREPK?2p,证实抗体对磷酸化 tau 的高亲和力及选择性捕获能力[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

1. Posdinemab (1-60 mg/kg;单次;静脉注射) 显示良好安全性和耐受性,血清药代动力学呈线性,脑脊液 (CSF) 中游离及总 p217+tau 水平呈剂量依赖性下降[1]
2. Posdinemab 可用于检测 CSF 中双磷酸化 tau 肽 SRTPSLPTPPTREPK?2p (含 pT217 位点) ,且处理后的总p217+tau水平下降[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
基因 ID

4137  [NCBI]

Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

145.331 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Posdinemab
目录号:
HY-P9995
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