2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Procaterol

Procaterol  (Synonyms: 丙卡特罗; 美喘清; 丙卡特罗气雾剂)

目录号: HY-114732
产品使用指南 技术支持

Procaterol 是一种可口服的选择性 β2 adrenergic receptor 激动剂。Procaterol可通过环磷酸腺苷依赖性机制直接抑制嗜酸性粒细胞迁移和 BEAS-2B 细胞释放嗜酸性粒细胞趋化活性因子。Procaterol对大鼠的支气管扩张作用和代谢作用存在较大的剂量差，可用于运动员哮喘研究。

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Procaterol

Procaterol Chemical Structure

CAS No. : 72332-33-3

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Procaterol 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes[1].

IC50 & Target[1]

β2 adrenoceptor

 

体外研究
(In Vitro)

Procatero (10-1000 ng/mL, 12, 24, 48 h, BEAS-2B) 通过环 AMP 依赖性机制直接抑制嗜酸性粒细胞迁移和 BEAS-2B 细胞中嗜酸性粒细胞趋化因子的释放[3]。
Procaterol (10-1000 ng/mL, 12, 24, 48 h, BEAS-2B) 剂量依赖性抑制 BEAS-2B 细胞单层对 IL-1b 和 TNF-a 反应的 RANTES 释放, 在 IL-1b 作用下增强 GM-CSF mRNA 的表达[3]。
Procaterol (0.1 μM, 72 h, Human tracheal surface epithelial cells) 可降低鼻病毒滴度和 RNA、细胞因子浓度、鼻病毒感染易感性、14 型鼻病毒受体细胞间粘附分子-1 (ICAM-1) 的表达以及鼻病毒 RNA 进入细胞质的细胞内酸性内体的数量[4]。
Procaterol (10 nM, one time, Lung ephelial cells) 通过 cAMP 以剂量依赖的方式增加 ciliary bend amplitude (CBA) 和 ciliary beating frequency (CBF)[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Procaterol 相关抗体:

Cell Migration Assay [3]

Cell Line: eosinophil
Concentration: 10, 100, 1000 ng/mL
Incubation Time: 24 h
Result: Attenuated the eosinophil migratory response in a dose-dependent.
体内研究
(In Vivo)

Procaterol (0.03-1 mg/kg, inhalation 3 times a day, 14 days) 大鼠腓肠肌的重量或体重增加没有明显变化[1]。
Procaterol (1 mg/kg, inhalation 3 times a day, 14 days) 显著地增加了提肛肌的重量，有合成代谢作用[1]。
Procaterol (1 mg/kg, inhalation 3 times a day, 14 days) 增加腹侧前列腺重量与药物对组织中b2肾上腺素受体的刺激有关[1]。
Procaterol (1 mg/kg, inhalation 3 times a day, 14 days) 的支气管扩张作用与合成代谢作用的剂量差异大于 30 倍，小于100 倍[2]。
Procaterol (0.1, 1, 10 mg/kg, orally, before ovalbumin (HY-W250978) (OVA) inhalation) 吸入不会增强气道高反应性、气道壁炎症或气道壁增厚，并能减少嗜酸性粒细胞的数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old rats were castrated on Day – 5, except for a normal group of 6 rats[1]
Dosage: 0.03, 0.1, 0.3, 1 mg/mL
Administration: in-halation 3 times a day (09 : 00, 12 : 00, 16 : 00) for 14 days from Day 0 to Day 13.
Result: No significant changed in weight or body weight gain in rat gastrocnemius muscle. Significantly increased the weight of the levator ani muscle. Increasd in ventral prostate weight.
Animal Model: Mice immunized with ovalbumin (HY-W250978) (OVA, inhalation of 20 mg/mL OVA for 10 minutes every other day, total 7 times) + alum[2]
Dosage: 0.1, 1, 10 mg/kg
Administration: orally, before ovalbumin (HY-W250978) (OVA) inhalation
Result: Inhalation did not enhance airway hyperresponsiveness, airway wall inflammation, or airway wall thickening after OVA inhalation.
Reduced the number of eosinophils in BALF mice.
Clinical Trial
分子量

290.36

Formula

C16H22N2O3
CAS 号
中文名称

丙卡特罗
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Procaterol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procaterol72332-33-3丙卡特罗Adrenergic ReceptorBeta Receptorselectiveagonistin-haledBEAS-2Basthmacastrated ratInhibitorinhibitorinhibit

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